作者投稿
专家审稿
编辑办公
Analysis of the Development and Detection Requirements for Repetitive Transcranial Magnetic Stimulation
-
摘要: 作为一种重要的康复理疗设备和非侵入式神经调控技术，重复经颅磁刺激治疗仪在精神类疾病治疗和脑功能调控等领域发挥着重要作用。重复经颅磁刺激治疗仪使用脉冲磁场直接作用于人脑，脉冲磁场的磁感应强度、输出频率等特性直接决定刺激安全性和有效性。在研究了经颅磁刺激治疗仪技术发展的基础上，介绍了重复经颅磁刺激治疗仪的技术原理，详细描述重复经颅磁刺激治疗仪检测技术的研究路径。通过仿真技术获得典型刺激线圈产生的脉冲磁场分布，获得了灰质层上磁感应强度最大位置的大致范围；通过调研试制电磁感应线圈并进行实验，证明了电磁感应法测量脉冲磁场的可行性。针对重复经颅磁刺激治疗仪研发的检测技术不仅可以用于临床在用设备的检测，也能服务于脑功能调控等前沿科研领域，为落实“健康中国2030”战略提供技术保障。Abstract: As an essential rehabilitation physiotherapy equipment and non-invasive neuromodulation technology, repetitive Transcranial Magnetic Stimulation (rTMS) plays a vital role in the treatment of psychiatric diseases and brain function modulation. Since rTMS uses the pulsed magnetic field to act directly on the human brain, the magnetic induction intensity and output frequency of the pulsed magnetic field determine the safety and effectiveness of stimulation. Starting with reviewing the development of TMS, the technical principle of rTMS was introduced, and the research path of its measurement was described in detail. In this paper, the distribution of pulsed magnetic field generated by a typical stimulation coil was obtained by simulation, which could specify the approximate position of the maximum value point of magnetic induction intensity in grey matter. The feasibility of the electromagnetic induction method for measuring pulsed magnetic field has been demonstrated through research and trial production of electromagnetic induction coils and experiments. The measurement method developed in this paper can not only be used for the detection of rTMS in use but also serve cutting-edge scientific research fields such as brain function modulation, contributing to the implementation of the Healthy China 2030 strategy.
-
图 2 圆形刺激线圈、同心球壳模体脉冲磁场仿真结果
Figure 2. Simulation results of pulsed magnetic field with circular stimulation coil and concentric spherical shell phantom
表 1 线圈中感应电动势测量结果
Table 1. Measurement results of induced electromotive force in the coil
刺激频率 10 Hz 10 Hz 20 Hz 20 Hz 充电电压 500 V 1000 V 500 V 1000 V 感应电动势频率 10 Hz 10 Hz 20 Hz 20 Hz 感应电动势峰值电压 2.2 V 5.1 V 2.3 V 8.2 V 
下载: 导出CSV
-
[1] BARKER A T, JALINOUS R, FREESTON I L. Non-invasive Magnetic Stimulation of the Human Motor Cortex[J]. Lancet, 1985, 1(8437): 1106-1107. [2] 李江涛, 郑敏军, 曹辉. 经颅磁刺激技术的研究进展[J]. 高压电技术, 2016, 42(4): 1168-1178. [3] 中国医师协会神经调控专业委员会电休克与神经刺激学组. 重复经颅磁刺激治疗专家共识[J]. 转化医学杂志, 2018, 7(1): 4-9. [4] JEAN-PASCAL L, ANDRÉ A, CHRIS B, et al. Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS): An update (2014–2018)[J]. Clinical Neurophysiology, 2020, 131(2): 474-528. doi: 10.1016/j.clinph.2019.11.002 [5] JIN L, XIUFENG X, YUEQIN H, et al. Prevalence of depressive disorders and treatment in China: a cross-sectional epidemiological study[J]. Lancet Psychiatry, 2021, 8: 981-990. doi: 10.1016/S2215-0366(21)00251-0 [6] 弗若斯特沙利文咨询公司. 中国康复医疗器械市场研究[R]. 北京: 弗若斯特沙利文咨询公司, 2019. [7] 杨春林. 便携式经颅磁刺激系统设计与研究 [D]. 秦皇岛: 燕山大学, 2016 . [8] 王华建. 经颅磁刺激系统控制电路设计及其仿真分析 [D]. 天津: 河北工业大学, 2007 . [9] SIMONE R, MARK H, PAOLO M R, et al. Safety, ethical considerations, and application guidelines for the use of transcranial magnetic stimulation in clinical practice and research[J]. Clinical Neurophysiology, 2009, 120(12): 2008-2039. doi: 10.1016/j.clinph.2009.08.016 [10] SIMONE R, ANDREA A, SVEN B, et al. Safety and recommendations for TMS use in healthy subjects and patient populations, with updates on training, ethical and regulatory issues: Expert Guidelines[J]. Clinical Neurophysiology, 2021, 132(1): 269-306. doi: 10.1016/j.clinph.2020.10.003 [11] DONGHYEON K, JINMO J, SANGDO J, et al. Validation of computational studies for electrical brain stimulation with phantom head experiments[J]. Brain Stimulation, 2015, 8(5): 914-924. doi: 10.1016/j.brs.2015.06.009 [12] MAI L, SHOOGO U. Computational Study Toward Deep Transcranial Magnetic Stimulation Using Coaxial Circular Coils[J]. IEEE Transactions on Biomedical Engineering, 2015, 62(12): 2911-2919. doi: 10.1109/TBME.2015.2452261 [13] 黄熠, 刘 新, 王玉凤, 等. 重复经颅磁刺激在神经退行性疾病中的应用进展[J]. 中国临床医学, 2020, 27(4): 689-692. doi: 10.12025/j.issn.1008-6358.2020.20192177 [14] 于淼, 姜炜. 重复经颅磁刺激在精神疾病中的应用[J]. 国际精神病学杂志, 2019, 46(2): 197-198. [15] Fitzgerald P . EEG and fMRI network-based predictors of response to rTMS in depression[J]. Brain Stimulation, 2019, 12(2):395-396. -
点击查看大图
图(2) / 表(1)
计量
- 文章访问数: 652
- HTML全文浏览量: 309
- PDF下载量: 45
- 被引次数: 0
