头发中药物残留分析技术的研究进展

韦棋; 苏福海

doi:10.12338/j.issn.2096-9015.2023.0103

头发中药物残留分析技术的研究进展

doi: 10.12338/j.issn.2096-9015.2023.0103

韦棋,
苏福海^,

中国计量科学研究院，北京 100029

基金项目: 国家重点研发计划 ( 2018YFC0807301-4)。

详细信息

作者简介:
韦棋（ 1995-），中国计量科学研究院研究实习员，研究方向：有机化学计量，邮箱：weiqi@nim.ac.cn

通讯作者:
苏福海（ 1976-），中国计量科学研究院副研究员，研究方向：有机分析，邮箱：sufh@nim.ac.cn

中图分类号: TB99
计量
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- HTML全文浏览量: 186
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- 被引次数: 0
出版历程
- 收稿日期: 2023-04-07
- 录用日期: 2023-04-10
- 修回日期: 2023-05-22
- 网络出版日期: 2023-07-24
- 刊出日期: 2023-05-31

Advancements in Drug Residue Analysis Techniques in Hair

WEI Qi,
SU Fuhai^,

National Institute of Metrology, Beijing 100029, China

摘要

摘要: 与其他生物样本相比，头发检测的主要优势在于检测窗口更宽。头发分析的前处理过程要比常规基质更加繁琐，主要包括采样、清洗、水解和提取净化等。用于头发中药物分析的方法主要有免疫分析法、色谱法、气相色谱/串联质谱法（GC-MS/MS）、液相色谱/串联质谱法（LC-MS/MS）等，因其高灵敏度和高选择性，GC-MS/MS和LC-MS/MS是头发中药物分析技术常用的分析方法。头发分析可提供药物成瘾史或药物毒性的相关信息，是法庭科学领域研究的热点之一，目前头发基质标准物质的相关研究较少，主要集中在违禁药物领域。回顾了过去几十年的相关研究，介绍了头发中药物分析技术和相关标准物质的研究进展。通过查阅相关文献，从头发中药物分析技术的特点、前处理过程、分析方法、应用以及相关标准物质的研究现状五个方面，对头发中药物分析技术和相关标准物质的研究进展进行综述。
- 计量学 /
- 头发 /
- 药物分析 /
- 气相色谱/串联质谱法 /
- 液相色谱/串联质谱法 /
- 标准物质
Abstract: Compared to other biological samples, hair offers an extended window for drug detection. The pre-treatment process in hair analysis is notably more complex than standard matrices, involving procedures such as sampling, cleaning, hydrolysis, and extraction purification. Techniques employed for drug residue analysis in hair encompass immunoassays, chromatographic methods, gas chromatography-tandem mass spectrometry (GC-MS/MS), and liquid chromatography-tandem mass spectrometry (LC-MS/MS). Owing to their high sensitivity and selectivity, GC-MS/MS and LC-MS/MS serve as the prevalent methods for drug analysis in hair. Hair analysis can furnish information pertaining to a history of drug addiction or drug toxicity, making it a subject of keen interest in forensic science research. Presently, research related to hair matrix standard materials is rather sparse, predominantly concentrating on prohibited drugs. This article reviews the development over the past few decades in hair drug analysis techniques and related standard materials. By examining the relevant literature, this review presents an overview of the research progress in hair drug analysis techniques and associated reference materials, focusing on their characteristics, pre-treatment processes, analytical methods, applications, and the current state of related reference material research.
- metrology /
- hair /
- pharmaceutical analysis /
- GC-MS/MS /
- LC-MS/MS /
- reference materials

HTML全文

图 1 药物进入头发的途径

Figure 1. Pathway of drug entry into hair

下载: 全尺寸图片幻灯片

图 2 头发分析的前处理过程

Figure 2. Pre-treatment process in hair analysis

下载: 全尺寸图片幻灯片

图 3 头发分析的工作流程

Figure 3. Workflow of hair analysis

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