甲状腺功能检查项目的检测标准化现状

吴梅燃; 韩丽乔; 张乔轩

doi:10.12338/j.issn.2096-9015.2024.0132

甲状腺功能检查项目的检测标准化现状

doi: 10.12338/j.issn.2096-9015.2024.0132

吴梅燃^{1, 2,},
韩丽乔^{1, 2},
张乔轩^{1, 2, ,}

1.
广州中医药大学第二附属医院（广东省中医院），广州 510120
2.
广州中医药大学第二临床医学院，广州 510120

基金项目: 国家重点研发计划(2022YFC3602300, 2022YFC3602301)。

详细信息

作者简介:
吴梅燃（1999-），广州中医药大学硕士研究生，研究方向：临床检验标准化，邮箱：wumeiran991108@163.com

通讯作者:
张乔轩（1987-），广东省中医院副研究员，研究方向：临床检验标准化与疾病早期诊断，邮箱：zhangqiaoxuan123@163.com

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- 文章访问数: 82
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- PDF下载量: 10
- 被引次数: 0
出版历程
- 收稿日期: 2024-04-18
- 录用日期: 2024-07-01
- 修回日期: 2024-06-20
- 网络出版日期: 2024-08-02

Current situation of thyroid function test standardization

WU Meiran^{1, 2
,},
HAN Liqiao^{1, 2},
ZHANG Qiaoxuan^{1, 2
, ,}

1.
Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, China
2.
The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, China

摘要

摘要: 临床上甲状腺功能的检测指标有促甲状腺激素、三碘甲状腺原氨酸、甲状腺素、游离三碘甲状腺原氨酸、游离甲状腺素、抗甲状腺过氧化物酶抗体、抗促甲状腺激素受体抗体及甲状腺球蛋白抗体。甲状腺功能检测项目实现标准化和一致化有利于甲状腺疾病的诊疗。目前已有部分小分子激素类的项目可以实现标准化，但蛋白类的检测项目由于检测的复杂性，实现标准化依然存在问题和挑战。综述了甲状腺功能检查指标的检测方法、影响不同方法间结果可比性的原因、以及不同检测项目的标准化进展和问题。
- 计量学 /
- 甲状腺功能检测 /
- 甲状腺激素 /
- 临床检验标准化 /
- 参考方法 /
- 标准物质
Abstract: The clinical indicators for detecting thyroid function include triiodothyronine, thyroxine, free triiodothyronine, free thyroxine, thyroid stimulating hormone, thyroid peroxidase antibodies, anti-thyrotropin receptor antibody, and thyroglobulin antibodies. Thyroid illness diagnosis and therapy benefit from the standardization and consistency of thyroid function testing programs. At present, some small-molecule hormone items can already achieve standardization, but for protein detection items, due to the complexity of the measurement, there are still difficulties and challenges to achieving standardization. This article summarizes the detection methods of thyroid function examination indicators, the reasons that affect the comparability of results between different methods, and the standardization progress and problems of different detection items.
- metrology /
- thyroid function testing /
- thyroid hormones /
- clinical laboratory standardization /
- reference measurement procedure /
- reference material

HTML全文

图 1 甲状腺激素的合成与代谢

Figure 1. Synthesis and metabolism of thyroid hormones

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表 1 甲状腺功能指标变化的临床意义

Table 1. The clinical significance of changes in thyroid function indicators

	TT3	FT3	TT4	FT4	TSH	TPOAb	TGAb	TRAb
甲状腺功能亢进症	↑	↑	↑	↑	↓	正常或↑	正常或↑	正常或↑
甲状腺功能减退症	↓	↓	↓	↓	↑	正常或↑	正常或↑	NA
桥本氏甲状腺炎	正常	正常	正常	正常	正常	↑	↑	NA
亚急性甲状腺炎	↑	↑	↑	↑	↓	NA	NA	NA
甲状腺结节	正常	正常	正常	正常	正常	NA	NA	NA
注：TT3：总三碘甲状腺原氨酸；FT3：游离三碘甲状腺原氨酸；TT4：总甲状腺素；FT4：游离甲状腺素；TSH：促甲状腺激素；↑：升高；↓：下降；NA：无特殊情况时，不考虑该指标的变化情况。

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