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Detection and Standardization of Homovanillic Acid and Vanillylmandelic Acid
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摘要: 高香草酸(homovanillic acid , HVA)和香草扁桃酸(vanillylmandelic acid , VMA)是儿茶酚胺的终末代谢产物。检测尿液中的HVA和VMA不仅可以间接反应体内儿茶酚胺的分泌情况，而且对神经母细胞瘤和嗜铬细胞瘤等中枢神经系统疾病的早期诊断及鉴别具有重要的意义。目前虽已有许多检测HVA和VMA的方法，但在相同和不同的机构间检测同一样本所测得的检验结果存在较大差异。因此，建立参考方法、确立参考系统、实现HVA和VMA检测结果的准确与可比、实现检测结果的溯源和检验标准化是临床检验领域中新的目标与挑战。综述了检测HVA和VMA的临床意义、检测方法、以及标准化现状。Abstract: Homovanillic acid (HVA) and vanillylmandelic acid (VMA) are end metabolites of catecholamines. Measurement of HVA and VMA in urine not only serves as an indirect indicator of catecholamine secretion in the body but also holds significant importance in the early diagnosis and differential diagnosis of central nervous system diseases such as neuroblastoma and pheochromocytoma. Although various methods for detecting HVA and VMA are available, significant discrepancies exist in the results obtained from the same sample when tested within or across different institutions. Therefore, establishing reference methods and reference systems to ensure the accuracy and comparability of HVA and VMA measurement results, as well as traceability and standardization of testing, has become a new goal and challenge in the field of clinical detection. This article reviews the clinical significance, detection methods, and current status of standardization of HVA and VMA testing.
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Key words:
- metrology /
- homovanillic acid /
- vanillylmandelic acid /
- measurement methods /
- standardization
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