Volume 65 Issue 7
Jul.  2021
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LIU Shuhua, ZHANG Yiwen, WU Hong, ZHAO Haibo. Development and Uncertainty Evaluation of Reference Material of Caffeine Solution in Methanol-Water[J]. Metrology Science and Technology, 2021, 65(7): 28-33. doi: 10.12338/j.issn.2096-9015.2021.0027
Citation: LIU Shuhua, ZHANG Yiwen, WU Hong, ZHAO Haibo. Development and Uncertainty Evaluation of Reference Material of Caffeine Solution in Methanol-Water[J]. Metrology Science and Technology, 2021, 65(7): 28-33. doi: 10.12338/j.issn.2096-9015.2021.0027

Development and Uncertainty Evaluation of Reference Material of Caffeine Solution in Methanol-Water

doi: 10.12338/j.issn.2096-9015.2021.0027
  • Available Online: 2021-06-09
  • Publish Date: 2021-07-16
  • The reference material of caffeine in methanol-water for LC-MS calibration was developed, and uncertainty was evaluated. Using pure caffeine, chromatographic grade methanol, and laboratory first-grade water as raw materials, the purity of the pure caffeine product was verified by the mass balance method, and the standard method weight-volume method was used to prepare the reference material of the caffeine solution in methanol with a concentration of 9.94 mg/L. Liquid chromatography was used to compare the value of the 9.94 mg/L standard solutions of caffeine in methanol with the national certified reference material GBW(E)130453, and the uniformity, short-term stability, and long-term stability of the solution were studied. The results show that the developed 9.94 mg/L reference material of caffeine in methanol-water has good uniformity and stability, with a relative extended uncertainty of 2% (k=2) and a validity period of 12 months.
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  • [1]
    翟金晓, 高中勇, 赛雅雯, 等. 液相色谱-串联质谱法同时测定饮料中的咖啡因、茶碱和可可碱[J]. 中国卫生检验杂志, 2020, 30(2): 144-147.
    [2]
    陈尧, 周宏灏. 咖啡因体内代谢及其应用的研究进展[J]. 生理科学进展, 2020, 41(4): 256-260.
    [3]
    分析测试技术与仪器编辑部. 标准物质的作用[J]. 分析测试技术与仪器, 2001(2): 121.
    [4]
    李红梅. 标准物质及其在分析化学中的应用[M]. 北京: 中国计量出版社, 2006: 8-11.
    [5]
    中华人民共和国国家质量监督检验检疫总局. 标准物质通用技术与定义: JF 1005-2016[S]. 北京: 中国标准出版社, 2017.
    [6]
    金浩. 标准物质及应用技术[M]. 北京: 中国计量出版社, 2003: 90-107.
    [7]
    代妍, 张鹏辉, 白花, 等. 异丙醇-水中利血平溶液标准物质的研制[J]. 化学试剂, 2015, 37(8): 725-728.
    [8]
    全国标准物质管理委员会. 标准物质的研制管理与应用[M]. 北京: 中国计量出版社, 2010: 38-122.
    [9]
    国家标准物质研究中心. 一级标准物质技术规范: JJF 1006-1994[S]. 北京: 国家技术监督局, 1994.
    [10]
    李红梅. 标准物质质量控制及不确定度评定[M]. 北京: 中国标准出版社, 2014.
    [11]
    郑晓艳. 液相色谱及液质联用技术在环境分析中的应用[J]. 资源节约与环保, 2016(8): 50-53. doi: 10.3969/j.issn.1673-2251.2016.08.044
    [12]
    国家标准化管理委员会. 标准样品工作导则(3)标准样品定值的一般原则和统计方法: GB/T15000.3 -2008[S]. 北京: 中国标准出版社, 2008.
    [13]
    Steven Westwood, Tiphaine Choteau, Adeline Daireaux, et al. Mass Balance Method for the SI Value Assignment of the Purity of Organic Compounds[J]. American Chemical Society, 2013, 85: 3118-3126.
    [14]
    国家质量监督检验检疫总局. 测量不确定度评定与表示: JJF1059.1-2012[S]. 北京: 中国标准出版社, 2013.
    [15]
    国家质量监督检验检疫总局. 标准物质定值的通用原则及统计学原理: JJF1343-2012[S].北京: 中国质检出版社, 2012.
    [16]
    国家质量监督检验检疫总局 中国国家标准化管理委员会. 化工产品中水分含量的测定卡尔费休法(通用方法): GB/T 6283-2008[S]. 北京: 中国标准出版社, 2009.
    [17]
    陈玲, 白英臣, 周瑾艳, 等. 质量平衡法测定八氟萘的纯度[J]. 中国标准化, 2019(14): 163-165. doi: 10.3969/j.issn.1002-5944.2019.14.074
    [18]
    孙雨安, 宋世丘, 王国庆, 等. 微波消解/ICP-MS法测定烟草中微量元素含量[J]. 光谱学与光谱分析, 2010(7):1968-1971.
    [19]
    王菊香,刘洁,韩晓. 卡尔费休容量滴定法测定混胺燃料中水含量[J]. 化学分析计量, 2013, 22(1): 67-69. doi: 10.3969/j.issn.1008-6145.2013.01.019
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