Purity Determination of Five Typical Endocrine Disrupting Compounds by Differential Scanning Calorimetry

ZHANG Siyao; LI Xiaomin; WANG Haifeng; CHEN Dongliang; ZHANG Qinghe

doi:10.12338/j.issn.2096-9015.2021.0644

Volume 66 Issue 7

Aug. 2022

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ZHANG Siyao, LI Xiaomin, WANG Haifeng, CHEN Dongliang, ZHANG Qinghe. Purity Determination of Five Typical Endocrine Disrupting Compounds by Differential Scanning Calorimetry[J]. Metrology Science and Technology, 2022, 66(7): 22-27. doi: 10.12338/j.issn.2096-9015.2021.0644

Citation:

ZHANG Siyao, LI Xiaomin, WANG Haifeng, CHEN Dongliang, ZHANG Qinghe. Purity Determination of Five Typical Endocrine Disrupting Compounds by Differential Scanning Calorimetry[J]. Metrology Science and Technology, 2022, 66(7): 22-27. doi: 10.12338/j.issn.2096-9015.2021.0644

Citation:

ZHANG Siyao, LI Xiaomin, WANG Haifeng, CHEN Dongliang, ZHANG Qinghe. Purity Determination of Five Typical Endocrine Disrupting Compounds by Differential Scanning Calorimetry[J]. Metrology Science and Technology, 2022, 66(7): 22-27. doi: 10.12338/j.issn.2096-9015.2021.0644

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Purity Determination of Five Typical Endocrine Disrupting Compounds by Differential Scanning Calorimetry

doi: 10.12338/j.issn.2096-9015.2021.0644

1.
National Institute of Metrology, Beijing 100029, China
2.
Beijing University of Chemical Technology, Beijing 100029, China

Available Online: 2022-04-24
Publish Date: 2022-08-04

Abstract

Abstract

As endocrine-disrupting compounds, 4-octylphenol, 4-nonylphenol, ethinylestradiol, hexestrol, and dienestrol have been detected in water, soil and food, and their certified reference materials are in wide market demand. In this paper, the purity of the five organic compounds was analyzed by differential scanning calorimetry (DSC), and joint research was carried out by high-performance liquid chromatography (HPLC) and thermal gravimetric analysis (TGA). The results showed that the purity of 4-octylphenol, 4-nonylphenol, ethinylestradiol, and hexestrol could be determined by DSC, and the results were in good agreement with those of the HPLC method. Since there was no obvious endothermic curve of dienestrol observed by DSC combined with TGA which revealed the decomposition of dienestrol during melting. It is concluded that the DSC method is not applicable for the purity analysis of dienestrol.
- differential scanning calorimetry,
- thermal gravimetric analysis,
- endocrine-disrupting compounds,
- purity analysis

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References(24)

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