Research Progress of Metal Organic Frameworks in Tumor Marker

LU Xin; HU Yalin; QU Ziyu; SHEN Liyue; DONG Jiahui; XIE Jie; PENG Tao

doi:10.12338/j.issn.2096-9015.2022.0287

Volume 67 Issue 4

Apr. 2023

Turn off MathJax

Article Contents

Article Navigation > Metrology Science and Technology > 2023 > 67(4): 37-45, 10

LU Xin, HU Yalin, QU Ziyu, SHEN Liyue, DONG Jiahui, XIE Jie, PENG Tao. Research Progress of Metal Organic Frameworks in Tumor Marker[J]. Metrology Science and Technology, 2023, 67(4): 37-45, 10. doi: 10.12338/j.issn.2096-9015.2022.0287

Citation:

LU Xin, HU Yalin, QU Ziyu, SHEN Liyue, DONG Jiahui, XIE Jie, PENG Tao. Research Progress of Metal Organic Frameworks in Tumor Marker[J]. Metrology Science and Technology, 2023, 67(4): 37-45, 10. doi: 10.12338/j.issn.2096-9015.2022.0287

Citation:

PDF( 1644 KB)

Research Progress of Metal Organic Frameworks in Tumor Marker

doi: 10.12338/j.issn.2096-9015.2022.0287

LU Xin^1
,,
HU Yalin^{1, 2},
QU Ziyu¹,
SHEN Liyue^{1, 2},
DONG Jiahui^{1, 2},
XIE Jie¹,
PENG Tao^{1
,
,}

1.
National Institute of Metrology, Beijing 100029, China
2.
China Jiliang University, Hangzhou 310018, China

Received Date: 2022-11-25
Accepted Date: 2022-12-26
Rev Recd Date: 2022-12-23

Available Online: 2023-07-07

Publish Date: 2023-04-18

Abstract

Abstract

Cancer's potent concealment and rapid progression significantly impact patient treatment. Detecting tumor markers produced during cancer's development is of paramount clinical importance for early diagnosis, improving prognosis, and reducing cancer mortality. However, tumor markers' specificity and sensitivity are insufficient, and single tumor marker detection increases the likelihood of misdiagnosis or missed diagnosis, hindering differential diagnosis for specific tumor types. The detection methods for tumor markers are complicated, time-consuming, and costly, limiting their clinical application. Additionally, the generally low levels of tumor markers and complex matrix composition in the human body present challenges for the sensitivity and accuracy of detection techniques. In recent years, metal-organic frameworks (MOFs) have been extensively employed in the development of biosensors and tumor marker detection due to their unique and superior physicochemical properties. This study briefly summarizes the structure, naming methods, and functions of MOFs, compares the inherent characteristics, advantages, and disadvantages of each type of MOFs, and reviews the application progress of MOFs in tumor marker screening. The existing problems and development suggestions are summarized in the hope of providing references for the development of novel, high-sensitivity detection methods for tumor markers.
- metrology,
- cancer,
- metal-organic frameworks,
- tumor markers,
- biosensors

FullText(HTML)

References(63)

References

[1]	SUNG H, FERLAY J, SIEGEL R L, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries [J]. CA Cancer J Clin, 2021, 71(3): 209-249.
[2]	SOKOLL L J, CHAN D W. Chapter 44 - Tumor markers [M]. Academic Press, 2020: 779-793.
[3]	DUFFY M J. Tumor markers in clinical practice: A review focusing on common solid cancers [J]. Medical Principles and Practice, 2013, 22(1): 4-11.
[4]	SHI L, SHAO J, JING X, et al. Autoluminescence-Free Dual Tumor Marker Biosensing by Persistent Luminescence Nanostructures [J]. ACS Sustainable Chemistry & Engineering, 2020, 8(1): 686-694.
[5]	张亚杰, 姬爱国. 乳腺癌病理诊断中免疫组织化学检测意义分析 [J]. 系统医学, 2021, 6(23): 40-43.
[6]	JEONG S, PARK M-J, SONG W, et al. Current immunoassay methods and their applications to clinically used biomarkers of breast cancer [J]. Clinical Biochemistry, 2020, 78: 43-57.
[7]	ZONG C, WU J, WANG C, et al. Chemiluminescence Imaging Immunoassay of Multiple Tumor Markers for Cancer Screening [J]. Analytical Chemistry, 2012, 84(5): 2410-2415.
[8]	YIN S, MA Z. Electrochemical immunoassay for tumor markers based on hydrogels [J]. Expert Rev Mol Diagn, 2018, 18(5): 457-465.
[9]	LIU L, HAO Y, DENG D, et al. Nanomaterials-Based Colorimetric Immunoassays [J]. Nanomaterials (Basel), 2019, 9(3): 316-347.
[10]	TAZAWA H, SHIGEYASU K, NOMA K, et al. Tumor-targeted fluorescence labeling systems for cancer diagnosis and treatment [J]. Cancer Sci, 2022, 113(6): 1919-1929.
[11]	YAGHI O M, LI G, LI H. Selective binding and removal of guests in a microporous metal–organic framework [J]. Nature, 1995, 378(6558): 703-706.
[12]	JAMES S L. Metal-organic frameworks [J]. Chem Soc Rev, 2003, 32(5): 276-288.
[13]	孟格. 过渡金属基纳米材料的设计合成及其在能源储存和转化中的应用 [D]. 北京: 北京化工大学, 2018.
[14]	李建惠, 兰天昊, 陈杨, 等. MOF复合材料在气体吸附分离中的研究进展 [J]. 化工学报, 2021, 72(1): 167-179.
[15]	刘震震. 金属有机骨架(Cu-MOF)催化NH_3-SCR反应去除NO的研究 [D]. 大连: 大连理工大学, 2016.
[16]	汪碧如. MOF纳米复合材料的制备及其在电化学发光生物传感中的应用 [D]. 武汉: 华中农业大学, 2018.
[17]	沈宏. 核壳型MOF用于细胞内pH和酶的逐步响应成像 [D]. 南京: 南京大学, 2018.
[18]	陈玉平, 武鹤松, 陆欢, 等. 家蚕丝素蛋白诱导金属-有机骨架材料(MOF)构建核-壳结构的pH响应性抗癌药物载体[C]. 镇江: 中国蚕学会第十届青年学术研讨会, 2019.
[19]	FURUKAWA H, CORDOVA K E, O'KEEFFE M, et al. The chemistry and applications of metal-organic frameworks [J]. Science, 2013, 341(6149): 1230444.
[20]	WANG Y, YAN J, WEN N, et al. Metal-organic frameworks for stimuli-responsive drug delivery [J]. Biomaterials, 2020, 230: 119619.
[21]	韩蕊. 铁基MOFs复合材料在化学发光适配体传感器中的应用 [D]. 济南: 济南大学, 2021.
[22]	GHANBARI T, ABNISA F, WAN DAUD W M A. A review on production of metal organic frameworks (MOF) for CO2 adsorption [J]. Science of The Total Environment, 2020, 707: 135090.
[23]	EVANS J D, GARAI B, REINSCH H, et al. Metal–organic frameworks in Germany: From synthesis to function [J]. Coordination Chemistry Reviews, 2019, 380: 378-418.
[24]	BHARDWAJ N, BHARDWAJ S K, MEHTA J, et al. MOF-Bacteriophage Biosensor for Highly Sensitive and Specific Detection of Staphylococcus aureus [J]. ACS Appl Mater Interfaces, 2017, 9(39): 33589-33598.
[25]	程绍娟. 金属有机骨架配合物MOF-5的合成及其储氢性能研究 [D]. 太原: 太原理工大学, 2007.
[26]	许兰兰, 王松, 刘玉霞, 等. 微波法合成金属-有机骨架材料研究应用进展 [J]. 化工新型材料, 2019, 47(4): 1-5.
[27]	WEN T, QUAN G, NIU B, et al. Versatile Nanoscale Metal-Organic Frameworks (nMOFs): An Emerging 3D Nanoplatform for Drug Delivery and Therapeutic Applications [J]. Small, 2021, 17(8): e2005064.
[28]	WANG H S. Metal–organic frameworks for biosensing and bioimaging applications [J]. Coordination Chemistry Reviews, 2017, 349: 139-155.
[29]	JOSEPH J, IFTEKHAR S, SRIVASTAVA V, et al. Iron-based metal-organic framework: Synthesis, structure and current technologies for water reclamation with deep insight into framework integrity [J]. Chemosphere, 2021, 284: 131171.
[30]	LI J, LIU L, AI Y, et al. Self-Polymerized Dopamine-Decorated Au NPs and Coordinated with Fe-MOF as a Dual Binding Sites and Dual Signal-Amplifying Electrochemical Aptasensor for the Detection of CEA [J]. ACS Applied Materials & Interfaces, 2020, 12(5): 5500-5510.
[31]	CHEN R, CHEN X, ZHOU Y, et al. "Three-in-One" Multifunctional Nanohybrids with Colorimetric Magnetic Catalytic Activities to Enhance Immunochromatographic Diagnosis [J]. ACS Nano, 2022, 16(2): 3351-3361.
[32]	SHU Y, YE Q, DAI T, et al. Encapsulation of Luminescent Guests to Construct Luminescent Metal–Organic Frameworks for Chemical Sensing [J]. ACS Sensors, 2021, 6(3): 641-658.
[33]	ZHANG X, LI G, WU D, et al. Recent progress in the design fabrication of metal-organic frameworks-based nanozymes and their applications to sensing and cancer therapy [J]. Biosensors and Bioelectronics, 2019, 137: 178-198.
[34]	LI X, LI X, LI D, et al. Electrochemical biosensor for ultrasensitive exosomal miRNA analysis by cascade primer exchange reaction and MOF@Pt@MOF nanozyme [J]. Biosensors and Bioelectronics, 2020, 168: 112554.
[35]	WANG Z, JIANG X, YUAN R, et al. N-(aminobutyl)-N-(ethylisoluminol) functionalized Fe-based metal-organic frameworks with intrinsic mimic peroxidase activity for sensitive electrochemiluminescence mucin1 determination [J]. Biosensors and Bioelectronics, 2018, 121: 250-256.
[36]	LI C, LI Y, ZHANG Y, et al. Signal-enhanced electrochemiluminescence strategy using iron-based metal-organic frameworks modified with carboxylated Ru(II) complexes for neuron-specific enolase detection [J]. Biosensors and Bioelectronics, 2022, 215: 114605.
[37]	WANG M, HU M, LI Z, et al. Construction of Tb-MOF-on-Fe-MOF conjugate as a novel platform for ultrasensitive detection of carbohydrate antigen 125 and living cancer cells [J]. Biosensors and Bioelectronics, 2019, 142: 111536.
[38]	LI H, EDDAOUDI M, O'KEEFFE M, et al. Design and synthesis of an exceptionally stable and highly porous metal-organic framework [J]. Nature, 1999, 402(6759): 276-279.
[39]	ZHOU N, SU F, GUO C, et al. Two-dimensional oriented growth of Zn-MOF-on-Zr-MOF architecture: A highly sensitive and selective platform for detecting cancer markers [J]. Biosensors and Bioelectronics, 2019, 123: 51-58.
[40]	BAHARI D, BABAMIRI B, MORADI K, et al. Graphdiyne nanosheet as a novel sensing platform for self-enhanced electrochemiluminescence of MOF enriched ruthenium (II) in the presence of dual co-reactants for detection of tumor marker [J]. Biosensors and Bioelectronics, 2022, 195: 113657.
[41]	MO G, HE X, QIN D, et al. A potential-resolved electrochemiluminescence resonance energy transfer strategy for the simultaneous detection of neuron-specific enolase and the cytokeratin 19 fragment [J]. Analyst, 2021, 146(4): 1334-1339.
[42]	MA E, WANG P, YANG Q, et al. Electrochemical Immunosensors for Sensitive Detection of Neuron-Specific Enolase Based on Small-Size Trimetallic Au@Pd^Pt Nanocubes Functionalized on Ultrathin MnO(2) Nanosheets as Signal Labels [J]. ACS Biomater Sci Eng, 2020, 6(3): 1418-1427.
[43]	WEI Q, WANG C, ZHOU X, et al. Ionic liquid and spatially confined gold nanoparticles enhanced photoelectrochemical response of zinc-metal organic frameworks and immunosensing squamous cell carcinoma antigen [J]. Biosensors and Bioelectronics, 2019, 142: 111540.
[44]	CAVKA J H, JAKOBSEN S, OLSBYE U, et al. A New Zirconium Inorganic Building Brick Forming Metal Organic Frameworks with Exceptional Stability [J]. Journal of the American Chemical Society, 2008, 130(42): 13850-13851.
[45]	韩易潼, 刘民, 李克艳, 等. 高稳定性金属有机骨架UiO-66的合成与应用 [J]. 应用化学, 2016, 33(4): 367-378.
[46]	BAO T, FU R, WEN W, et al. Target-Driven Cascade-Amplified Release of Loads from DNA-Gated Metal–Organic Frameworks for Electrochemical Detection of Cancer Biomarker [J]. ACS Applied Materials & Interfaces, 2020, 12(2): 2087-2094.
[47]	XIONG X, ZHANG Y, WANG Y, et al. One-step electrochemiluminescence immunoassay for breast cancer biomarker CA 15-3 based on Ru(bpy)62+-coated UiO-66-NH2 metal-organic framework [J]. Sensors and Actuators B: Chemical, 2019, 297: 126812.
[48]	WU Y, HAN J, XUE P, et al. Nano metal–organic framework (NMOF)-based strategies for multiplexed microRNA detection in solution and living cancer cells [J]. Nanoscale, 2015, 7(5): 1753-1759.
[49]	WEI Y P, ZHANG Y W, MAO C J. A silver nanoparticle-assisted signal amplification electrochemiluminescence biosensor for highly sensitive detection of mucin 1 [J]. J Mater Chem B, 2020, 8(12): 2471-2475.
[50]	HUANG X, HE Z, GUO D, et al. "Three-in-one" Nanohybrids as Synergistic Nanoquenchers to Enhance No-Wash Fluorescence Biosensors for Ratiometric Detection of Cancer Biomarkers [J]. Theranostics, 2018, 8(13): 3461-3473.
[51]	BANERJEE A, SINGH U, ARAVINDAN V, et al. Synthesis of CuO nanostructures from Cu-based metal organic framework (MOF-199) for application as anode for Li-ion batteries [J]. Nano Energy, 2013, 2(6): 1158-1163.
[52]	HATAMI Z, JALALI F, AMOUZADEH TABRIZI M, et al. Application of metal-organic framework as redox probe in an electrochemical aptasensor for sensitive detection of MUC1 [J]. Biosensors and Bioelectronics, 2019, 141: 111433.
[53]	ZHOU L, YANG L, WANG C, et al. Copper doped terbium metal organic framework as emitter for sensitive electrochemiluminescence detection of CYFRA 21-1 [J]. Talanta, 2022, 238: 123047.
[54]	XIE J, CHENG D, LI P, et al. Au/Metal–Organic Framework Nanocapsules for Electrochemical Determination of Glutathione [J]. ACS Applied Nano Materials, 2021, 4(5): 4853-4862.
[55]	HAN W, HUANG X, LU G, et al. Research Progresses in the Preparation of Co-based Catalyst Derived from Co-MOFs and Application in the Catalytic Oxidation Reaction [J]. Catalysis Surveys from Asia, 2019, 23(2): 64-89.
[56]	DAI L, LI Y, WANG Y, et al. A prostate-specific antigen electrochemical immunosensor based on Pd NPs functionalized electroactive Co-MOF signal amplification strategy [J]. Biosensors and Bioelectronics, 2019, 132: 97-104.
[57]	XU W, QIN Z, HAO Y, et al. A signal-decreased electrochemical immunosensor for the sensitive detection of LAG-3 protein based on a hollow nanobox-MOFs/AuPt alloy [J]. Biosensors and Bioelectronics, 2018, 113: 148-156.
[58]	ZHANG Y, LI N, XU Y, et al. An ultrasensitive dual-signal aptasensor based on functionalized Sb@ZIF-67 nanocomposites for simultaneously detect multiple biomarkers [J]. Biosensors and Bioelectronics, 2022, 214: 114508.
[59]	WANG S, ZHAO Y, WANG M, et al. Enhancing Luminol Electrochemiluminescence by Combined Use of Cobalt-Based Metal Organic Frameworks and Silver Nanoparticles and Its Application in Ultrasensitive Detection of Cardiac Troponin I [J]. Analytical Chemistry, 2019, 91(4): 3048-3054.
[60]	AFZALINIA A, MIRZAEE M. Ultrasensitive Fluorescent miRNA Biosensor Based on a "Sandwich" Oligonucleotide Hybridization and Fluorescence Resonance Energy Transfer Process Using an Ln(III)-MOF and Ag Nanoparticles for Early Cancer Diagnosis: Application of Central Composite Design [J]. ACS Appl Mater Interfaces, 2020, 12(14): 16076-16087.
[61]	陆洪军, 杨小宁, 沙靖全, 等. β-环糊精金属有机骨架材料的合成及对阿奇霉素的包合研究 [J]. 哈尔滨理工大学学报, 2015, 20(4): 35-40.
[62]	WANG Y, LI Y, ZHUANG X, et al. Ru(bpy)32+ encapsulated cyclodextrin based metal organic framework with improved biocompatibility for sensitive electrochemiluminescence detection of CYFRA21-1 in cell [J]. Biosensors and Bioelectronics, 2021, 190: 113371.
[63]	MA H, LI X, YAN T, et al. Electrochemiluminescent immunosensing of prostate-specific antigen based on silver nanoparticles-doped Pb (II) metal-organic framework [J]. Biosensors and Bioelectronics, 2016, 79: 379-385.