Progress in Peptide Chemical Synthesis and its Metrology

ZHAO Yue; ZHAO Haibo; LENG Xiaojing; ZHAO Xiaoning; WANG Bingyue

doi:10.12338/j.issn.2096-9015.2024.0215

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Article Navigation > Metrology Science and Technology > 2024 > Accepted Manuscript

ZHAO Yue, ZHAO Haibo, LENG Xiaojing, ZHAO Xiaoning, WANG Bingyue. Progress in Peptide Chemical Synthesis and its Metrology[J]. Metrology Science and Technology. doi: 10.12338/j.issn.2096-9015.2024.0215

Citation:

ZHAO Yue, ZHAO Haibo, LENG Xiaojing, ZHAO Xiaoning, WANG Bingyue. Progress in Peptide Chemical Synthesis and its Metrology[J]. Metrology Science and Technology. doi: 10.12338/j.issn.2096-9015.2024.0215

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Progress in Peptide Chemical Synthesis and its Metrology

doi: 10.12338/j.issn.2096-9015.2024.0215

1.
Beijing Institute of Metrology, Beijing 100029, China
2.
China Agricultural University, College of Food Science and Nutritional Engineering, Beijing 100081, China

Received Date: 2024-06-30
Accepted Date: 2024-07-09
Rev Recd Date: 2024-07-31

Available Online: 2024-09-05

Abstract

Abstract

Peptides are an important class of organic molecules in life bodies, and they participate in life activities together with proteins. Peptides, which have strong biological activity and biological functions, have been widely used in new materials, biological medicine, food, cosmetics and other fields. And they have tremendous social and economic value. In recent years, the rapid development of peptide synthesis technology, especially the rapid development of peptide chemical synthesis method, has greatly accelerated the development and application of peptide products. In the face of more and more peptide products on the market, the market demand for biological activity analysis of peptide compounds is increasing. And at the same time, the standardization of quality control of peptide products is also put forward. As a science of measurement, metrology technology can ensure that the measurement results can be reproduced and traced, and plays a critical role in the development and production of peptides and the quality control of related products. Developing peptide/protein metrology, which focuses on the research to achieve the accuracy and consistency of biological measurement and to ensure the measurement results can be traced to the international system of Units (SI), is an urgent and arduous task for metrology workers. This paper comprehensively introduces the chemical synthesis strategies of peptides, along with the advantages and disadvantages of these strategies, and application values. Meanwhile, the development, application and challenges of peptide/protein metrology are also introduced. This article intends to provide a reference for the quality control of peptide/protein products.
- metrology,
- peptides,
- solution-phase synthesis,
- solid-phase synthesis,
- reference materials

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References(48)

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