Abstract: Most continuous on-line gas detection alarms output 4–20 mA analog electrical signals. These devices involve complex gas types, numerous manufacturers, a wide variety of specifications and models, and require intricate wiring operations during calibration. Currently, no calibration system can efficiently handle the calibration of various alarms with 4–20 mA analog signal outputs, resulting in low calibration efficiency. This paper presents a calibration system based on embedded configuration software (MCGS), which offers universality and can automatically collect, intelligently process, and judge the results of multiple gas detection alarm signals simultaneously. Experimental results show that the electrical signals collected by the calibration system are accurate and reliable. During the ventilation test, the indication errors among the channels were relatively consistent, and the overall trend of the indication error was aligned between the system's automatic calculations and the data obtained from the national verification regulation's prescribed method. The system's automatic calculation function significantly improves the calibration efficiency of gas detection alarms.