甲状腺功能检查项目的检测标准化现状

    Current situation of thyroid function test standardization

    • 摘要: 临床上甲状腺功能的检测指标有促甲状腺激素、三碘甲状腺原氨酸、甲状腺素、游离三碘甲状腺原氨酸、游离甲状腺素、抗甲状腺过氧化物酶抗体、抗促甲状腺激素受体抗体及甲状腺球蛋白抗体。甲状腺功能检测项目实现标准化和一致化有利于甲状腺疾病的诊疗。目前已有部分小分子激素类的项目可以实现标准化,但蛋白类的检测项目由于检测的复杂性,实现标准化依然存在问题和挑战。综述了甲状腺功能检查指标的检测方法、影响不同方法间结果可比性的原因、以及不同检测项目的标准化进展和问题。

       

      Abstract: The clinical indicators for detecting thyroid function include triiodothyronine, thyroxine, free triiodothyronine, free thyroxine, thyroid stimulating hormone, thyroid peroxidase antibodies, anti-thyrotropin receptor antibody, and thyroglobulin antibodies. Thyroid illness diagnosis and therapy benefit from the standardization and consistency of thyroid function testing programs. At present, some small-molecule hormone items can already achieve standardization, but for protein detection items, due to the complexity of the measurement, there are still difficulties and challenges to achieving standardization. This article summarizes the detection methods of thyroid function examination indicators, the reasons that affect the comparability of results between different methods, and the standardization progress and problems of different detection items.

       

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