质子放射治疗参考剂量研究进展概述

齐雅平; 霍万里; 金孙均; 黄骥; 王志鹏; 张健; 王坤

doi:10.12338/j.issn.2096-9015.2021.0649

质子放射治疗参考剂量研究进展概述

doi: 10.12338/j.issn.2096-9015.2021.0649

齐雅平^1,,
霍万里²,
金孙均¹,
黄骥¹,
王志鹏¹,
张健¹,
王坤^1, ,

1.
中国计量科学研究院，北京 100029
2.
中国计量大学，杭州 310018

基金项目: 国家重点研发计划（2021YFF0603600）；中国计量科学研究院重点领域基本业务费（AKYZD1908）；浙江省自然基金（LQ21A050003）；安徽省重点研发计划（202104h04020038）。

详细信息

作者简介:
齐雅平（1992-），中国计量科学研究院助理研究员，研究方向：质子放疗、辐射生物效应，邮箱：qiyp@nim.ac.cn

通讯作者:
王坤（1980-），中国计量科学研究院研究员，研究方向：电离辐射计量，邮箱：wangkun@nim.ac.cn

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出版历程
- 网络出版日期: 2021-12-31

Overview of the Research Progress of Reference Dosimetry in Proton Radiotherapy

1.
National Institute of Metrology, Beijing 100029, China
2.
China Jiliang University, Hangzhou 310018, China

摘要

摘要: 质子放射治疗因质子在深度剂量上具有布拉格峰特性而逐渐成为一种精准放疗技术。本文介绍了三种质子束参考剂量测量方法，总结了其局限性，并借助蒙特卡洛模拟方法对测量方法的修正项及改进方法进行了讨论，最后概述了微剂量测量的最新进展，为国内研究质子束水吸收剂量测量工作提供了参考。
- 质子放射治疗 /
- 参考剂量 /
- 量热法 /
- 电离室 /
- 微剂量
Abstract: Proton radiotherapy has gradually become a precision radiotherapy technique owing to the characteristic of Bragg Peak on the depth-dose distribution. This paper introduces the details of three proton beam reference dosimetry methods as well as the corresponding limitations in clinical proton modalities. Further discussions on the correction terms and improvement methods of measurements combined with Monte Carlo techniques have been proposed. Finally, the state-of-the-art determination on microdosimetry of proton beams has been summarized, which provides a reference for research on proton beam water absorption dose measurement.
- proton radiotherapy /
- reference dosimetry /
- calorimetry /
- ionization chamber /
- microdosimetry

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表 1 质子水量热实验及修正因子汇总

Table 1. Summary of proton water calorimeters and correction factors

文献年份	METAS 2005^[13]	PTB 2006^[22]	METAS 2010^[23]	隆德大学2006^[17]/2010^[14]	麦吉尔大学2010^[12]/2016^{[12, 24]}	格罗宁根大学2018^[19]
射线质	214 MeV¹	32 MeV¹/182 MeV²	250 MeV¹	175 MeV¹/180 MeV¹	235 MeV^1,2/60 MeV²	190 MeV²
质子束来源	瑞士PSI	德国HMI/南非iThemba	瑞士PSI	瑞典TSL	美国MGH/英国 CCC	德国AGOR
水等校测量深度	-	20 mm/-	16.8 cm³	10 cm/6 cm	131.15 mm/11 mm	5 cm
量热芯 (形状/材质/壁厚)	圆柱/玻璃/-	平板/镀金铝/0.3 mm	圆柱/玻璃/1 mm	圆柱/玻璃/1 mm	平板/玻璃/1.12 mm	圆柱&平板/ 玻璃/1 mm
超纯水系统	N₂饱和	-	N₂饱和	N₂饱和	H₂饱和	H₂饱和
k_HD	0 ± 0.3%	0.4%/(0.3% ± 0.3%)	0	0.09%	0	0
合成不确定度	-	1.5%/1.4%	5%	0.5%	0.4%/0.6%	0.12%
注：¹代表扫描束； ²代表散射束；³代表实际测量深度。

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表 2 蒙特卡洛方法计算质子束辐射质转换因子研究

Table 2. Monte Carlo calculated k_Q factors of proton beams

文献	蒙特卡洛软件	电离室型号（数量）	质子束¹(参考深度²)
Gomà, et al^[46]	PENH	Exradin A10, A11, A11TW+, NACP-02, PPC-05, PPC-40, Advanced Markus 34045, Markus 23343, Roos34001, FC65-G, FC65-P, NE2571（12个）	70, 100, 150, 00, 250 MeV (2g·cm^-2)
Sorriaux, et al^[45]	Geant4/GATE/TOPAS	Roos, FC65-G（2个）	SOBP (300mm)
Lourenço, et al ^[44]	FLUKA	Roos34001, PTW34070, PTW34073（3个）	60, 150, 250MeV (1~2cm)
Wulff, et al^[43]	Geant4/TOPAS	NACP02, NE2571（2个）	70, 100, 150, 200, 250 MeV (2g·cm^-2）
Gomà, et al^[41]	PENH	Exradin A10, A11, A11TW+, NACP-02, PPC-05, PPC-40, Advanced Markus 34045, Markus 23343, Roos 34001, FC65-G, FC65-P, NE2571, PTW30013，Exradin A12, A19（15个）	60, 70, 80, 100, 150, 160, 200, 250MeV； SOBP（1~10g·cm^-2）
Bauman, et al^[47]	FLUKA/PENH/TOPAS/GEANT4	NACP02, Roos34001, Exradin A12, NE2571（4个³）	150MeV (2g·cm^-2）
Bauman, et al^[42]	TOPAS/ GEANT4	Roos, Markus, Advanced Markus, NACP02, PPC-05, PPC-40, NE 2571, 30013, FC65-G, Exradin A1SL（10个）	60, 70, 80, 100, 150, 160, 200, 250MeV (1~2g·cm^-2)
Kretschmer, et al^[48]	GATE/ GEANT4	NE2571, PTW30013, PTW31014, PTW31021, PTW31022（5个）	70, 100, 150, 200, and 250 MeV (2cm)
注：¹表示无特殊标识均为单能质子束; ²表示TRS-398报告中质子束电离室测量的参考深度为3g·cm⁻²；³表示简单几何建模。

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