留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

质子放射治疗参考剂量研究进展概述

齐雅平 霍万里 金孙均 黄骥 王志鹏 张健 王坤

齐雅平,霍万里,金孙均,等. 质子放射治疗参考剂量研究进展概述[J]. 计量科学与技术,待出版. doi: 10.12338/j.issn.2096-9015.2021.0649
引用本文: 齐雅平,霍万里,金孙均,等. 质子放射治疗参考剂量研究进展概述[J]. 计量科学与技术,待出版. doi: 10.12338/j.issn.2096-9015.2021.0649
QI Yaping, HUO Wanli, JIN Sunjun, HUANG Ji, WANG Zhipeng, ZHANG Jian, WANG Kun. Reviews of the Research Progresses in reference dosimetry of Proton Radiotherapy[J]. Metrology Science and Technology. doi: 10.12338/j.issn.2096-9015.2021.0649
Citation: QI Yaping, HUO Wanli, JIN Sunjun, HUANG Ji, WANG Zhipeng, ZHANG Jian, WANG Kun. Reviews of the Research Progresses in reference dosimetry of Proton Radiotherapy[J]. Metrology Science and Technology. doi: 10.12338/j.issn.2096-9015.2021.0649

质子放射治疗参考剂量研究进展概述

doi: 10.12338/j.issn.2096-9015.2021.0649
基金项目: 国家重点研发计划(2021YFF0603600);重点领域基本业务费(AKYZD1908);浙江省自然基金(LQ21A050003);安徽省重点研发计划(202104h04020038)。
详细信息
    作者简介:

    齐雅平(1992-),中国计量科学研究院助理研究员,研究方向:质子放疗、辐射生物效应,邮箱:qiyp@nim.ac.cn;通讯作者:

    王坤(1980-),中国计量科学研究院副所长,研究员,研究方向:电离辐射计量,邮箱:wangkun@nim.ac.cn

Reviews of the Research Progresses in reference dosimetry of Proton Radiotherapy

  • 摘要: 质子放射治疗因质子在深度剂量上具有布拉格峰特性而逐渐成为一种精准放疗技术。本文介绍了三种质子束参考剂量测量方法,总结了其局限性,并借助蒙特卡洛模拟方法对测量方法的修正项及改进方法进行了讨论,最后延展了微剂量测量的最新进展,为国内研究质子束水吸收剂量测量工作提供了参考。
  • 表  1  质子水量热实验及修正因子汇总

    Table  1.   Summary of proton water calorimeters and corrected factors

    文献-年份METAS-2005[13]PTB-2006[22]METAS-2010[23]隆德大学2006[17]/2010[14]麦吉尔大学-2010[12]/2016[12,24]格罗宁根大学-2018[19]
    射线质214 MeV132 MeV1/182 MeV2250 MeV1175 MeV1/180 MeV1235 MeV1,2/60 MeV2190 MeV2
    质子束来源瑞士PSI德国HMI/南非iThemba瑞士PSI瑞典TSL美国MGH/英国 CCC德国AGOR
    水等校测量深度-20 mm/-16.8 cm310 cm/6 cm131.15 mm/11 mm5 cm
    量热芯
    (形状/材质/壁厚)
    圆柱/玻璃/-平板/镀金铝/0.3 mm圆柱/玻璃/1 mm圆柱/玻璃/1 mm平板/玻璃/1.12 mm圆柱&平板/
    玻璃/1 mm
    超纯水系统N2饱和-N2饱和N2饱和H2饱和H2饱和
    kHD0 ± 0.3%0.4%/0.3% ± 0.3%00.09%00
    合成不确定度-1.5%/1.4%5%0.5%0.4%/0.6%0.12%
    1代表扫描束; 2代表散射束;3实际测量深度。
    下载: 导出CSV

    表  2  蒙特卡洛方法计算质子束辐射质转换因子研究

    Table  2.   Monte Carlo calculated kQ factors of proton beams

    文献蒙卡软件电离室型号(数量)质子束1(参考深度2)
    Gomà et al[46]PENHExradin A10, A11, A11TW+, NACP-02, PPC-05, PPC-40,
    Advanced Markus 34045, Markus 23343, Roos34001,
    FC65-G, FC65-P, NE2571(12个)
    70, 100, 150, 00,
    250 MeV (2g·cm-2)
    Sorriaux et al[45]Geant4/GATE/TOPASRoos, FC65-G(2个)SOBP (300mm)
    Lourenço et al [44]FLUKARoos34001, PTW34070, PTW34073(3个)60, 150, 250MeV (1-2cm)
    Wulff et al[43]Geant4/TOPASNACP02, NE2571(2个)70, 100, 150, 200,
    250 MeV (2g·cm-2
    Gomà et al[41]PENHExradin A10, A11, A11TW+, NACP-02, PPC-05, PPC-40,
    Advanced Markus 34045, Markus 23343, Roos 34001, FC65-G,
    FC65-P, NE2571, PTW30013,Exradin A12, A19(15个)
    60, 70, 80, 100, 150,
    160, 200, 250MeV;
    SOBP(1-10g·cm-2
    Bauman et al[47]FLUKA/PENH/TOPAS/GEANT4NACP02, Roos34001, Exradin A12, NE2571(4个3150MeV (2g·cm-2
    Bauman et al[42]TOPAS/ GEANT4Roos, Markus, Advanced Markus, NACP02, PPC-05,
    PPC-40, NE 2571, 30013, FC65-G, Exradin A1SL(10个)
    60, 70, 80, 100, 150, 160,
    200, 250MeV (1-2g·cm-2)
    Kretschmer et al[48]GATE/ GEANT4NE2571, PTW30013, PTW31014, PTW31021, PTW31022(5个)70, 100, 150, 200,
    and 250 MeV (2cm)
    1无特殊标识均为单能质子束; 2TRS-398报告中质子束电离室测量的参考深度为3g·cm-23简单几何建模
    下载: 导出CSV
  • [1] PAGANETTI H, KOOY H. Proton radiation in the management of localized cancer[J]. Expert Rev Med Devices, 2010, 7(2): 275-85. doi: 10.1586/erd.10.2
    [2] PTCOG.https://www.ptcog.ch/index.php/facilities-under-construction.
    [3] INTERNATIONAL ATOMIC ENERGY AGENCY. Absorbed Dose Determination in External Beam Radiotherapy[M]. Vienna: IAEA, 2001.
    [4] DICELLO J, UNIVERSITY C, FESSENDEN P, et al. Protocol for heavy charged-particle therapy beam dosimetry [R]. AAPM Report, 1986, 16.
    [5] VYNCKIER S, BONNETT D E, JONES D. Code of practice for clinical proton dosimetry[R]. Radiotherapy & Oncology Journal of the European Society for Therapeutic Radiology & Oncology, 1991, 20 (1): 53-63.
    [6] VYNCKIER S, BONNETT D E, JONES D. Supplement to the code of practice for clinical proton dosimetry[J]. Radiotherapy & Oncology Journal of the European Society for Therapeutic Radiology & Oncology, 1994, 32(2): 174.
    [7] KACPEREK A. Clinical Proton Dosimetry Part I: Beam Production, Beam Delivery and Measurement of Absorbed Dose (ICRU Report 59)[R]. Physics in Medicine & Biology, 2000, 45 (10): 3123.
    [8] MUSOLINO S V. Absorbed Dose Determination in External Beam Radiotherapy: An International Code of Practice for Dosimetry Based on Standards of Absorbed Dose to Water; Technical Reports Series No. 398[R]. Health Physics, 2001, 81 (5): 592-593.
    [9] JR D L, WAMBERSIE A, WHITMORE G. ICRU Report 78, Precribing, recording, and reporting proton-beam therapy [R]. Journal of the ICRU, 2007, 7 (2): 1-210.
    [10] 王坤, 金孙均, 王志鹏, 等. 医用加速器光子水吸收剂量量值体系的研究与应用[J]. 中国计量, 2019(7): 4.
    [11] KARGER C P, JAKEL O, PALMANS H, et al. Dosimetry for ion beam radiotherapy[J]. Phys Med Biol, 2010, 55(21): 193-234. doi: 10.1088/0031-9155/55/21/R01
    [12] SARFEHNIA A, CLASIE B, CHUNG E, et al. Direct absorbed dose to water determination based on water calorimetry in scanning proton beam delivery[J]. Med Phys, 2010, 37(7): 3541-50.
    [13] SASSOWSKY M, PEDRONI E. On the feasibility of water calorimetry with scanned proton radiation[J]. Phys Med Biol, 2005, 50(22): 5381-400. doi: 10.1088/0031-9155/50/22/011
    [14] MEDIN J. Implementation of water calorimetry in a 180 MeV scanned pulsed proton beam including an experimental determination of kQ for a Farmer chamber[J]. Phys Med Biol, 2010, 55(12): 3287-98. doi: 10.1088/0031-9155/55/12/002
    [15] LOURENçO A, THOMAS R, BOUCHARD H, et al. Experimental and Monte Carlo studies of fluence corrections for graphite calorimetry in low- and high-energy clinical proton beams[J]. Med Phys, 2016, 43(7): 4122. doi: 10.1118/1.4951733
    [16] ROSSOMME S, PALMANS H, THOMAS R, et al. Reference dosimetry for light-ion beams based on graphite calorimetry[J]. Radiat Prot Dosimetry, 2014, 161(1-4): 92-5. doi: 10.1093/rpd/nct299
    [17] MEDIN J, ROSS C K, KLASSEN N V, et al. Experimental determination of beam quality factors, kQ, for two types of Farmer chamber in a 10 MV photon and a 175 MeV proton beam[J]. Phys Med Biol, 2006, 51(6): 1503-21. doi: 10.1088/0031-9155/51/6/010
    [18] ROSS C K, KLASSEN N V. REVIEW ARTICLE: Water calorimetry for radiation dosimetry[J]. Physics in Medicine & Biology, 1996, 41(1): 1-29.
    [19] MULDER J. Water calorimetry for proton Implementing a primary dose measurement standard[D]. University of Groningen, 2018.
    [20] SHIN W G, RAMOS-MENDEZ J, TRAN N H, et al. Geant4-DNA simulation of the pre-chemical stage of water radiolysis and its impact on initial radiochemical yields[J]. Physica Medica, 2021, 88(77): 86-90.
    [21] GRASSBERGER C, PAGANETTI H. Elevated LET components in clinical proton beams[J]. Phys Med Biol, 2011, 56(20): 6677-91. doi: 10.1088/0031-9155/56/20/011
    [22] BREDE H J, GREIFf K D, HECKER O, et al. Absorbed dose to water determination with ionization chamber dosimetry and calorimetry in restricted neutron, photon, proton and heavy-ion radiation fields[J]. Physics in Medicine & Biology, 2006, 51(15): 3667-3682.
    [23] GAGNEBIN S, TWERENBOLD D, PEDRONI E, et al. Experimental determination of the absorbed dose to water in a scanned proton beam using a water calorimeter and an ionization chamber[J]. Nuclear Instruments and Methods in Physics Research Section B:Beam Interactions with Materials and Atoms, 2010, 268(5): 524-528. doi: 10.1016/j.nimb.2009.11.010
    [24] RENAUD J, ROSSOMME S, SARFEHNIA A, et al. Development and application of a water calorimeter for the absolute dosimetry of short-range particle beams[J]. Phys Med Biol, 2016, 61(18): 6602-6619. doi: 10.1088/0031-9155/61/18/6602
    [25] JAFFE G. Zur theory der ionization in kolonnen I[J]. Ann Physik, 2006, 341(12): 303-344.
    [26] ROSSOMME S, HOPFGARTNER J, LEE N D. Ion recombination correction in carbon ion beams[J]. Med. Phys., 2016, 43(7): 4198. doi: 10.1118/1.4953637
    [27] BOAG J W, HOCHHUSER E, BALK O A. The effect of free-electron collection on the recombination correction to ionization measurements of pulsed radiation[J]. Phys Med Biol, 1996, 41(5): 885-897. doi: 10.1088/0031-9155/41/5/005
    [28] ROSSOMME S, LORENTINI S, VYNCKIER S, et al. Correction of the measured current of a small-gap plane-parallel ionization chamber in proton beams in the presence of charge multiplication[J]. Zeitschrift für Medizinische Physik, 2021, 31(2): 192-202.
    [29] BHULLAR A S, WATCHMAN C J. The effective depth of cylindrical ionization chambers in water for clinical proton beams[J]. Phys Med Biol, 2012, 57(1): 273-86. doi: 10.1088/0031-9155/57/1/273
    [30] PALMANS H. Perturbation factors for cylindrical ionization chambers in proton beams. Part I: corrections for gradients[J]. Phys Med Biol, 2006, 51(14): 3483-3501. doi: 10.1088/0031-9155/51/14/014
    [31] HARTMANN G H, JÄKEL O, HEEG P, et al. Determination of water absorbed dose in a carbon ion beam using thimble ionization chambers[J]. Phys Med Biol, 1999, 44(5): 1193-1206. doi: 10.1088/0031-9155/44/5/008
    [32] JÄKEL, HARTMANN, HEEG, et al. Effective point of measurement of cylindrical ionization chambers for heavy charged particles[J]. Phys Med Biol, 2000, 45(3): 599-607. doi: 10.1088/0031-9155/45/3/303
    [33] SUGAMA Y, NISHIO T, ONISHI H. Technical Note: Experimental determination of the effective point of measurement of two cylindrical ionization chambers in a clinical proton beam[J]. Med Phys, 2015, 42(7): 3892-5. doi: 10.1118/1.4921617
    [34] BARNA S. Determination of the effective point of measurement of a ionization chamber in light-ion beams[C]. ESTRO 2021, 2021.
    [35] PALMANS H, MEDIN J, TRNKOVA P, et al. Gradient corrections for reference dosimetry using Farmer-type ionization chambers in single-layer scanned proton fields[J]. Med Phys, 2020, 47(12): 6531-6539. doi: 10.1002/mp.14554
    [36] GREVILLOT L, OSORIO M J, LETELLIER V, et al. Clinical implementation and commissioning of the MedAustron Particle Therapy Accelerator for non-isocentric scanned proton beam treatments[J]. Med Phys, 2020, 47(2): 380-392. doi: 10.1002/mp.13928
    [37] GOMA C, SAFAI S, VOROS S. Reference dosimetry of proton pencil beams based on dose-area product: a proof of concept[J]. Phys Med Biol, 2017, 62(12): 4991-5005. doi: 10.1088/1361-6560/aa7008
    [38] KUESS P, HAUPT S, OSORIO J, et al. Characterization of the PTW-34089 type 147 mm diameter large-area ionization chamber for use in light-ion beams[J]. Phys Med Biol, 2020, 65(17): 17NT02. doi: 10.1088/1361-6560/ab9852
    [39] FARR J B, MOSKVIN V, LUKOSE R C, et al. Technical Note: Design and characterization of a large diameter parallel plate ionization chamber for accurate integral depth dose measurements with proton beams[J]. Med Phys, 2020, 47(7): 3214-3224. doi: 10.1002/mp.14166
    [40] GOMA C, HOFSTETTER-BOILLAT B, SAFAI S, et al. Experimental validation of beam quality correction factors for proton beams[J]. Phys Med Biol, 2015, 60(8): 3207-16. doi: 10.1088/0031-9155/60/8/3207
    [41] GOMA C, STERPIN E. Monte Carlo calculation of beam quality correction factors in proton beams using PENH[J]. Phys Med Biol, 2019, 64(18): 185009. doi: 10.1088/1361-6560/ab3b94
    [42] BAUMANN K S, KAUPA S, BACH C, et al. Monte Carlo calculation of beam quality correction factors in proton beams using TOPAS/GEANT4[J]. Phys Med Biol, 2020, 65(5): 055015. doi: 10.1088/1361-6560/ab6e53
    [43] WULFF J, BAUMANN K S, VERBEEK N, et al. TOPAS/Geant4 configuration for ionization chamber calculations in proton beams[J]. Phys Med Biol, 2018, 63(11): 115013. doi: 10.1088/1361-6560/aac30e
    [44] LOURENçO A, BOUCHARD H, GALE R S, et al. The influence of nuclear interactions on ionization chamber perturbation factors in proton beams: FLUKA simulations supported by a Fano test[J]. Medical Physics, 2018, 46(2): 885-891.
    [45] SORRIAUX J, TESTA M, PAGANETTI H, et al. Consistency in quality correction factors for ionization chamber dosimetry in scanned proton beam therapy[J]. Medical physics, 2017, 44(9): 4919-4927. doi: 10.1002/mp.12434
    [46] GOMA C, ANDREO P, SEMPAU J. Monte Carlo calculation of beam quality correction factors in proton beams using detailed simulation of ionization chambers[J]. Phys Med Biol, 2016, 61(6): 2389-406. doi: 10.1088/0031-9155/61/6/2389
    [47] BAUMANN K S, HORST F, ZINK K, et al. Comparison of penh, fluka, and Geant4/topas for absorbed dose calculations in air cavities representing ionization chambers in high-energy photon and proton beams[J]. Med Phys, 2019, 46(10): 4639-4653. doi: 10.1002/mp.13737
    [48] KRETSCHMER J, DULKYS A, BRODBEK L, et al. Monte Carlo simulated beam quality and perturbation correction factors for ionization chambers in monoenergetic proton beams[J]. Med Phys, 2020, 47(11): 5890-5905. doi: 10.1002/mp.14499
    [49] LORIN S, GRUSELL E, TILLY N, et al. Reference dosimetry in a scanned pulsed proton beam using ionisation chambers and a Faraday cup[J]. Phys Med Biol, 2008, 53(13): 3519-3529. doi: 10.1088/0031-9155/53/13/008
    [50] PEDRONI E, SCHEIB S, BOHRINGER T, et al. Experimental characterization and physical modelling of the dose distribution of scanned proton pencil beams[J]. Phys Med Biol, 2005, 50(3): 541-61. doi: 10.1088/0031-9155/50/3/011
    [51] BORTOT D, POLA A, AGOSTEO S, et al. A novel avalanche-confinement TEPC for microdosimetry at nanometric level[J]. Radiation Measurements, 2017, 103: 1-12. doi: 10.1016/j.radmeas.2017.06.012
    [52] TSUDA S, SATO T, TAKAHASHI F, et al. Measurement of microdosimetric spectra with a wall-less tissue-equivalent proportional counter for a 290 MeV/u 12C beam[J]. Physics in Medicine & Biology, 2010, 55(17): 5089-101.
    [53] CONTE V, AGOSTEO S, BIANCHI A, et al. Microdosimetry of a therapeutic proton beam with a mini-TEPC and a MicroPlus-Bridge detector for RBE assessment[J]. Phys Med Biol, 2020, 65(24): 245018. doi: 10.1088/1361-6560/abc368
    [54] SCHREWE U J, NEWHAUSER W D, BREDE H J, et al. Experimental kerma coefficients and dose distributions of C, N, O, Mg, Al, Si, Fe, Zr, A-150 plastic, Al2O3, AlN, SiO2 and ZrO2 for neutron energies up to 66 MeV[J]. Phys Med Biol, 2000, 45(3): 651-683. doi: 10.1088/0031-9155/45/3/307
    [55] TRAN L T, CHARTIER L, PROKOPOVICH D A, et al. 3D-Mesa “Bridge” Silicon Microdosimeter: Charge Collection Study and Application to RBE Studies in C-12 Radiation Therapy[J]. IEEE Transactions on Nuclear Science, 2015, 62(2): 504-511. doi: 10.1109/TNS.2015.2391102
    [56] MALMER, CYNTHIA J. ICRU Report 63. Nuclear Data for Neutron and Proton Radiotherapy and for Radiation Protection[R]. Med Phys, 2001, 28 (5): 861.
    [57] SAWAKUCHI G O, FERREIRA F A, MCFADDEN C H, et al. Nanoscale measurements of proton tracks using fluorescent nuclear track detectors[J]. Med Phys, 2016, 43(5): 2485. doi: 10.1118/1.4947128
  • 加载中
计量
  • 文章访问数:  68
  • HTML全文浏览量:  27
  • PDF下载量:  27
  • 被引次数: 0
出版历程
  • 网络出版日期:  2021-12-31

目录

    /

    返回文章
    返回