眼科光学相干断层扫描计量研究进展

马祥; 洪宝玉; 刘文丽; 段亮成; 李修宇; 赵峻邦; 胡志雄

doi:10.12338/j.issn.2096-9015.2021.0657

眼科光学相干断层扫描计量研究进展

doi: 10.12338/j.issn.2096-9015.2021.0657

马祥^{1, 2,},
洪宝玉¹,
刘文丽¹,
段亮成¹,
李修宇³,
赵峻邦¹,
胡志雄^1, ,

1.
中国计量科学研究院，北京 100029
2.
中国计量大学，杭州 310018
3.
山东省计量科学研究院，济南 250014

基金项目: 国家质量基础的共性技术研究与应用重点专项(ZLJC1607-5);国家市场监督管理总局质量技术基础能力建设专项 (ANL2001);浙江省基础公益研究计划（LQ20F050009）。

详细信息

作者简介:
马祥（1984-），中国计量大学讲师，研究方向：医学图像处理等，邮箱：maxiang@cjlu.edu.cn

通讯作者:
胡志雄（1983-），中国计量科学研究院副研究员，研究方向：医学计量，邮箱：huzhixiong@nim.ac.cn

计量
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出版历程
- 录用日期: 2022-01-04
- 网络出版日期: 2022-01-10

Advances in Metrological Research of Optical Coherence Tomography in Ophthalmology

1.
National Institute of Metrology, Beijing 100029, China
2.
China Jiliang University, Hangzhou 310018, China
3.
Shandong Institute of Metrology, Jinan 250014, China

摘要

摘要: 从眼科OCT设备的原理、技术分类、商业发展、计量参数和标准器制作方面，讨论了眼科OCT的性能评价以及计量技术的发展。详细总结了眼科OCT设备的计量标准器、系统分辨率、信噪比/对比度、图像质量等计量评价手段方面的国内外研究进展，为眼科OCT技术标准化的进一步完善理清思路。
- 光学相干断层扫描 /
- 眼科 /
- 视网膜 /
- 模体 /
- 计量 /
- 标准
Abstract: This paper discussed the performance evaluation of ophthalmic Optical Coherence Tomography (OCT) and the development of metrology technology in terms of the principles, technical classification, commercial development, metrology parameters, and standard production of ophthalmic OCT devices. This paper summarized the domestic and foreign research progress of measurement and evaluation methods such as measurement standard, system resolution, signal-to-noise ratio/contrast, and image quality of ophthalmic OCT equipment in detail, and clarified the ideas for the further improvement of ophthalmic OCT technology standardization.
- optical coherence tomography /
- ophthalmology /
- retina /
- phantom /
- measurement /
- standard

HTML全文

图 1 时域OCT技术原理

Figure 1. The principle of Time-Domain OCT

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图 2 谱域OCT与扫频OCT技术原理

Figure 2. The principle of Spectral-Domain OCT and Swept-Source OCT

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图 3 ISO 16971-2015推荐的计量标准器

1. 总长度17 mm；2. 镜头f= 17 mm；3. 孔径，直径6 mm；4. 管；5. 直径为100 µm的张紧细丝；6. 中性密度滤光片；7 .玻璃平面，厚度1 mm；8. 标尺

Figure 3. Reference standard recommended by ISO 16971-2015

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图 4 一种包含前房结构的模拟眼装置设计图

Figure 4. Design of a phantom with anterior chamber

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图 5 基于人眼几何尺寸的OCT模体设计及实物图

Figure 5. Mechanical design and photograph of the phantom

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图 6 微米级尺寸的仿视锥细胞OCT模体

Figure 6. Micron-scale phantom mimics of cone cell

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图 7 三维分辨率板设计图及OCT成像结果

Figure 7. 3D resolution plate design and scan result

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图 8 多层膜结构模体在系统中成像对比度差异

Figure 8. Imaging contrast differences of multilayer film structure phantom in in broadband systems

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图 9 OCT系统主要计量参数的集成化测量校准装置

Figure 9. Integrated calibration device for OCT system

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