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眼科光学相干断层扫描计量研究进展

马祥 洪宝玉 刘文丽 段亮成 李修宇 赵峻邦 胡志雄

马祥,洪宝玉,刘文丽,等. 眼科光学相干断层扫描计量研究进展[J]. 计量科学与技术,待出版 doi: 10.12338/j.issn.2096-9015.2021.0657
引用本文: 马祥,洪宝玉,刘文丽,等. 眼科光学相干断层扫描计量研究进展[J]. 计量科学与技术,待出版 doi: 10.12338/j.issn.2096-9015.2021.0657
MA Xiang, HONG Baoyu, LIU Wenli, DUAN Liangcheng, LI Xiuyu, ZHAO Junbang, HU Zhixiong. Survey of Metrology on Optical Coherence Tomography in Ophthalmology[J]. Metrology Science and Technology. doi: 10.12338/j.issn.2096-9015.2021.0657
Citation: MA Xiang, HONG Baoyu, LIU Wenli, DUAN Liangcheng, LI Xiuyu, ZHAO Junbang, HU Zhixiong. Survey of Metrology on Optical Coherence Tomography in Ophthalmology[J]. Metrology Science and Technology. doi: 10.12338/j.issn.2096-9015.2021.0657

眼科光学相干断层扫描计量研究进展

doi: 10.12338/j.issn.2096-9015.2021.0657
基金项目: 国家质量基础的共性技术研究与应用重点专项(ZLJC1607-5);国家市场监督管理总局质量技术基础能力建设专项 (ANL2001);浙江省基础公益研究计划(LQ20F050009)。
详细信息
    作者简介:

    马祥(1984-),中国计量大学信息工程学院,讲师,研究方向:医学图像处理等,邮箱:maxiang@cjlu.edu.cn

    通讯作者:

    胡志雄(1983-),中国计量科学研究院副主任,副研究员,研究方向:医学计量,邮箱:huzhixiong@nim.ac.cn

Survey of Metrology on Optical Coherence Tomography in Ophthalmology

  • 摘要: 从眼科OCT设备的原理、技术分类、商业发展、计量参数和标准器制作方面,讨论了眼科OCT的性能评价以及计量技术的发展。详细总结了眼科OCT设备的计量标准器、系统分辨率、信噪比/对比度、图像质量等计量评价手段方面的国内外研究进展,为眼科OCT技术标准化的进一步完善理清思路。
  • 图  1  时域OCT技术原理

    Figure  1.  The principle of Time-Domain OCT

    图  2  谱域OCT与扫频OCT技术原理

    Figure  2.  The principles of Spectral-Domain OCT and Swept-Source OCT

    图  3  ISO 16971-2015推荐的计量标准器。

    1. 总长度17 mm;2. 镜头f= 17 mm;3. 孔径,直径6 mm;4. 管;5. 直径为100 µm的张紧细丝;6. 中性密度滤光片;7 .玻璃平面,厚度1 mm;8. 标尺

    Figure  3.  ISO 16971-2015 recommended phantom

    图  4  一种包含前房结构的模拟眼装置设计图

    Figure  4.  The design of a phantom with anterior chamber

    图  5  基于人眼几何尺寸的OCT模体设计及实物图(单位mm)

    Figure  5.  Mechanical design and photograph of a phantom

    图  6  微米级尺寸的仿视锥细胞OCT模体

    Figure  6.  Micron-scale phantom of cone

    图  7  三维分辨率板设计图及OCT成像结果

    Figure  7.  3D resolution plate design and scan result

    图  8  多层膜结构模体在系统中成像对比度差异

    Figure  8.  The difference in imaging contrast between the broadband systems of the multilayer film structure phantom

    图  9  OCT系统主要计量参数的集成化测量校准装置

    Figure  9.  Integrated calibration device for OCT system

  • [1] FUJIMOTO J G, PITRIS C, BOPPART S A, et al. Optical Coherence Tomography: An Emerging Technology for Biomedical Imaging and Optical Biopsy[J]. Neoplasia, 2000, 2(1): 9-25.
    [2] BILLE J F. High Resolution Imaging in Microscopy and Ophthalmology: New Frontiers in Biomedical Optics[M]. Springer International Publishing, 2019.
    [3] HUANG D, SWANSON E A, LIN C P, et al. Optical Coherence Tomography[J]. Science, 1991, 254(5035): 1178-1181. doi: 10.1126/science.1957169
    [4] FUJIMOTO J, SWANSON E. The Development, Commercialization, and Impact of Optical Coherence Tomography[J]. Investigative Ophthalmology & Visual Science, 2016, 57(9): OCT1-OCT13.
    [5] FERCHER A F, HITZENBERGER C K, KAMP G, et al. Measurement of Intraocular Distances by Backscattering Spectral Interferometry[J]. Optics Communications, 1995, 117(1): 43-48.
    [6] CHINN S R, SWANSON E A, FUJIMOTO J G. Optical Coherence Tomography Using a Frequency-Tunable Optical Source[J]. Optics Letters, 1997, 22(5): 340-342. doi: 10.1364/OL.22.000340
    [7] FERCHER A F, DREXLER W, HITZENBERGER C K. Optical Coherence Tomography - Principles and Applications[J]. Reports on Progress in Physics, 2003, 66(2): 239. doi: 10.1088/0034-4885/66/2/204
    [8] DREXLER W, LIU M, KUMAR A, et al. Optical coherence tomography today: speed, contrast, and multimodality[J]. Journal of Biomedical Optics, 2014, 19(7): 071412. doi: 10.1117/1.JBO.19.7.071412
    [9] REIF R, WANG R K. Optical Microangiography Based on Optical Coherence Tomography[M/OL]. DREXLER W, FUJIMOTO J G, //Optical Coherence Tomography: Technology and Applications. Cham: Springer International Publishing, 2015: 1373–1397.
    [10] SHU X, BECKMANN L J, ZHANG H F. Visible-light optical coherence tomography: a review[J]. Journal of Biomedical Optics, 2017, 22(12): 121707.
    [11] KIRBY M A, PELIVANOV I, SONG S, et al. Optical coherence elastography in ophthalmology[J]. Journal of Biomedical Optics, 2017, 22(12): 121720.
    [12] BOER J F de, HITZENBERGER C K, YASUNO Y. Polarization Sensitive Optical Coherence Tomography – a Review [Invited][J]. Biomedical Optics Express, 2017, 8(3): 1838-1873. doi: 10.1364/BOE.8.001838
    [13] JONNAL R S, KOCAOGLU O P, ZAWADZKI R J, et al. A Review of Adaptive Optics Optical Coherence Tomography: Technical Advances, Scientific Applications, and the Future[J]. Investigative Ophthalmology & Visual Science, 2016, 57(9): OCT51-OCT68.
    [14] PIRCHER M, ZAWADZKI R J. Review of Adaptive Optics OCT (AO-OCT): Principles and Applications for Retinal Imaging [Invited][J]. Biomedical Optics Express, 2017, 8(5): 2536-2562. doi: 10.1364/BOE.8.002536
    [15] KLEIN T, HUBER R. High-Speed OCT Light Sources and Systems [Invited][J]. Biomedical Optics Express, 2017, 8(2): 828-859. doi: 10.1364/BOE.8.000828
    [16] KIM T S, JOO J, SHIN I, et al. 9.4 MHz A-Line Rate Optical Coherence Tomography at 1300 Nm Using a Wavelength-Swept Laser Based on Stretched-Pulse Active Mode-Locking[J]. Scientific Reports, 2020, 10(1): 9328. doi: 10.1038/s41598-020-66322-0
    [17] KOVACH J L, SCHWARTZ S G, FLYNN H W, et al. Anti-VEGF Treatment Strategies for Wet AMD[J]. Journal of Ophthalmology, 2012: e786870.
    [18] MINAKARAN N, DE CARVALHO E R, PETZOLD A, et al. Optical Coherence Tomography (OCT) in Neuro-Ophthalmology[J]. Eye, 2021, 35(1): 17-32. doi: 10.1038/s41433-020-01288-x
    [19] SHARMA D, AGRAWAL A, MATCHETTE L S, et al. Evaluation of a fiberoptic-based system for measurement of optical properties in highly attenuating turbid media.[J]. Biomedical engineering online, 2006, 5: 49-49. doi: 10.1186/1475-925X-5-49
    [20] WANG Q, YANG H, AGRAWAL A, et al. Measurement of internal tissue optical properties at ultraviolet and visible wavelengths: Development and implementation of a fiberoptic-based system[J]. OPTICS EXPRESS, 2008, 16(12): 8685-8703. doi: 10.1364/OE.16.008685
    [21] WANG Q, AGRAWAL A, WANG N S, et al. Evaluation of a reflectance-based approach for optical property determination in layered tissue[C]//Design and Quality for Biomedical Technologies II. SPIE, 2009: 105–115.
    [22] WANG Q, AGRAWAL A, WANG N S, et al. Condensed Monte Carlo Modeling of Reflectance From Biological Tissue With a Single Illumination-Detection Fiber[J]. IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS, 2010, 16(3): 627-634. doi: 10.1109/JSTQE.2009.2029546
    [23] ZAWADZKI R J, ROWE T S, FULLER A R, et al. Toward building an anatomically correct solid eye model with volumetric representation of retinal morphology[C]//Ophthalmic Technologies XX. SPIE, 2010: 412–418.
    [24] ROWE T S, ZAWADZKI R J. New developments in eye models with retina tissue phantoms for ophthalmic optical coherence tomography[C]//Optical Diagnostics and Sensing XII: Toward Point-of-Care Diagnostics; and Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue IV. SPIE, 2012: 208–215.
    [25] ROWE T S, ZAWADZKI R J. Development of a corneal tissue phantom for anterior chamber optical coherence tomography (AC-OCT)[C]//Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue V. SPIE, 2013: 84–92.
    [26] AGRAWAL A, BAXI J, CALHOUN W, et al. Optic Nerve Head Measurements With Optical Coherence Tomography: A Phantom-Based Study Reveals Differences Among Clinical Devices[J]. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2016, 57(9): OCT413-OCT420.
    [27] LEE H-J, LEE H-J, SAMIUDIN N M, et al. Retina Phantom for the Evaluation of Optical Coherence Tomography Angiography Based on Microfluidic Channels[J]. Biomedical Optics Express, 2019, 10(11): 5535-5548. doi: 10.1364/BOE.10.005535
    [28] PFEFER J, AGRAWAL A. A review of consensus test methods for established medical imaging modalities and their implications for optical coherence tomography[C]//Design and Quality for Biomedical Technologies V. SPIE, 2012: 65–74.
    [29] 胡志雄, 郝冰涛, 孙欣, 等. 眼科光学相干断层(OCT)成像设备的计量研究[J]. 中国计量, 2016(07): 80-82.
    [30] 胡志雄, 刘文丽, 洪宝玉, 等. 光学相干层析成像三维分辨率测试模拟眼[J]. 光电工程, 2014, 41(12): 28-32+38.
    [31] 胡志雄, 郝冰涛, 刘文丽, 等. 用于光学相干层析成像设备点扩散函数测量的模体制作与使用方法研究[J]. 光学学报, 2015, 35(04): 283-289.
    [32] CAO Z, DING Z, HU Z, et al. A standard model eye with micro scale multilayer structure for ophthalmic optical coherence tomography equipment[C]//Optical Measurement Technology and Instrumentation. SPIE, 2016: 626–632.
    [33] TOMLINS P H, FERGUSON R A, HART C, et al. Point-Spread Function Phantoms for Optical Coherence Tomography. [EB/OL](2009–08).https://eprintspublications.npl.co.uk/4463/.
    [34] AGRAWAL A, PFEFER T J, GILANI N, et al. Three-Dimensional Characterization of Optical Coherence Tomography Point Spread Functions with a Nanoparticle-Embedded Phantom[J]. Optics Letters, 2010, 35(13): 2269-2271. doi: 10.1364/OL.35.002269
    [35] AGRAWAL A, CHANG R, CONNORS M, et al. System-independent assessment of OCT axial resolution with a 《bar chart》 phantom[C]. NORDSTROM R, COTE G .
    [36] AGRAWAL A, CONNORS M, BEYLIN A, et al. Characterizing the point spread function of retinal OCT devices with a model eye-based phantom[J]. BIOMEDICAL OPTICS EXPRESS, 2012, 3(5): 1116-1126. doi: 10.1364/BOE.3.001116
    [37] FOUAD A, PFEFER T J, CHEN C-W, et al. Variations in optical coherence tomography resolution and uniformity: a multi-system performance comparison[J]. BIOMEDICAL OPTICS EXPRESS, 2014, 5(7): 2066-2081. doi: 10.1364/BOE.5.002066
    [38] KEDIA N, LIU Z, SOCHOL R D, et al. 3-D printed photoreceptor phantoms for evaluating lateral resolution of adaptive optics imaging systems[J]. OPTICS LETTERS, 2019, 44(7): 1825-1828. doi: 10.1364/OL.44.001825
    [39] LAMONT A C, RESTAINO M A, ALSHARHAN A T, et al. Direct laser writing of a titanium dioxide-laden retinal cone phantom for adaptive optics-optical coherence tomography[J]. OPTICAL MATERIALS EXPRESS, 2020, 10(11): 2749-2759. doi: 10.1364/OME.396150
    [40] HU Z, HAO B, LIU W, et al. Test target for characterizing 3D resolution of optical coherence tomography[C]//International Symposium on Optoelectronic Technology and Application 2014: Laser and Optical Measurement Technology; and Fiber Optic Sensors. SPIE, 2014: 398–404.
    [41] FU X, HU Z, GE C, et al. A miniaturized and integrated system to measure key parameters of ophthamic optical coherence tomography equipment[C]//2015 International Conference on Optical Instruments and Technology: Optoelectronic Measurement Technology and Systems. SPIE, 2015: 124–132.
    [42] 付晓宇, 胡志雄, 葛春风, 等. 眼科光学相干层析成像设备分辨率关键参数的小型化检测装置研制[J]. 计量学报, 2017, 38(06): 690-692. doi: 10.3969/j.issn.1000-1158.2017.06.07
    [43] WEN T, DONG J, HU Z, et al. A standard test method based on point spread function for three-dimensional imaging system[C]//8th International Symposium on Advanced Optical Manufacturing and Testing Technologies: Optical Test, Measurement Technology, and Equipment. SPIE, 2016: 608–616.
    [44] CAO Z, DING Z, HU Z, et al. Model eyes with curved multilayer structure for the axial resolution evaluation of an ophthalmic optical coherence tomography device[J]. Journal of Innovative Optical Health Sciences, 2018, 11(03): 1850013. doi: 10.1142/S179354581850013X
    [45] HUANG N, DENG Z, HU Z, et al. A Spatial Resolution Evaluation Method of Endoscopic Optical Coherence Tomography System Using the Annular Phantom[J]. Journal of Biophotonics, 2021, 14(8): e202100035.
    [46] AGRAWAL A, HUANG S, WEI HAW LIN A, et al. Quantitative evaluation of optical coherence tomography signal enhancement with gold nanoshells.[J]. Journal of biomedical optics, 2006, 11(4): 041121-041121. doi: 10.1117/1.2339071
    [47] HEIKKA T, HEIKKA T, OMETTO G, et al. Testing a Phantom Eye under Various Signal-to-Noise Ratio Conditions Using Eleven Different OCT Devices[J]. Biomedical Optics Express, 2020, 11(3): 1306-1315. doi: 10.1364/BOE.383103
    [48] AGRAWAL A, CHEN C-W, BAXI J, et al. Multilayer thin-film phantoms for axial contrast transfer function measurement in optical coherence tomography[J]. BIOMEDICAL OPTICS EXPRESS, 2013, 4(7): 1166-1175. doi: 10.1364/BOE.4.001166
    [49] WOOLSEY N, WANG H-W, AGRAWAL A, et al. Quantitative analysis of low contrast detectability in optical coherence tomography[C]//Smart Biomedical and Physiological Sensor Technology XI. SPIE, 2014: 40–47.
    [50] AGRAWAL A, PFEFER T J, WOOLLIAMS P D, et al. Methods to assess sensitivity of optical coherence tomography systems[J]. BIOMEDICAL OPTICS EXPRESS, 2017, 8(2): 902-917. doi: 10.1364/BOE.8.000902
    [51] BAXI J, CALHOUN W, SEPAH Y J, et al. Retina-simulating phantom for optical coherence tomography[J]. JOURNAL OF BIOMEDICAL OPTICS, 2014, 19(2): 1106.
    [52] LOZZI A, AGRAWAL A, BORETSKY A, et al. Image quality metrics for optical coherence angiography[J]. BIOMEDICAL OPTICS EXPRESS, 2015, 6(7): 2435-2447. doi: 10.1364/BOE.6.002435
    [53] 李修宇, 吴福宝, 胡志雄, 等. 眼科光学相干断层扫描成像设备关键参数计量技术研究[J]. 中国医疗设备, 2019, 34(11): 16-21+29. doi: 10.3969/j.issn.1674-1633.2019.11.004
    [54] WANG H, LIU W, HU Z, et al. Model eye tool for retinal optical coherence tomography instrument calibration[J]. Journal of Innovative Optical Health Sciences, 2021, 14(03): 2150010. doi: 10.1142/S1793545821500103
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  • 录用日期:  2022-01-04
  • 网络出版日期:  2022-01-10

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