基于Lambert-Beer定律修正血氧饱和度<i>R</i>值曲线

马俊; 刘刚; 李超; 闻倩宇

doi:10.12338/j.issn.2096-9015.2022.0252

基于Lambert-Beer定律修正血氧饱和度R值曲线

doi: 10.12338/j.issn.2096-9015.2022.0252

北京市海淀区计量检测所，北京 100083

详细信息

作者简介:
马俊（1987-），北京市海淀区计量检测所工程师，研究方向：流量计量、医学计量等，邮箱：305171336@qq.com

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出版历程
- 网络出版日期: 2023-01-18

Correction and Calibration of R Value Curve for Blood Oxygen Saturation Measurement Model Based on Lambert-Beer Law

Haidian District Measurement and Testing Institute, Beijing 100083, China

摘要

摘要: 针对血氧模拟仪现有的R值曲线无法满足种类繁多的血氧仪计量检定需求，为解决血氧仪与模拟仪不兼容问题，提出一种基于Lambert-Beer定律的血氧饱和度测量模型的修正方法。在现有的检定装置上添加滤光介质，以实现在原有的测量模型上加一个修正值，从而对R值曲线进行修正。实验表明，通过添加滤光介质修正R值曲线，选择不同R值曲线检测血氧仪时均显示出正常的测量值，且示值重复性较小，符合国家计量检定规程要求，有效解决了血氧模拟仪与血氧仪之间的不兼容问题。
- Lambert-Beer定律 /
- 血氧饱和度 /
- 模拟仪 /
- R值曲线 /
- 检定
Abstract: The measurement of oxygen saturation in peripheral tissues is an important indicator of the oxygen supply to cells and tissues. However, with the emergence of a variety of new oximeters, the existing R value curve of oximetry simulation can no longer meet the current demand for metrological testing. To address this issue, a modified method of oxygen saturation measurement based on the Lambert-Beer law was proposed. This method involves the addition of an optical filter medium to the existing verification device to correct the R value curve and achieve a correction value added to the original measurement model. The experimental results demonstrate that by adding filter media to modify the R value curve, the oximeter can measure values that are close to the standard value under different R value curves. The indication repeatability is also small, meeting the requirements of national metrological verification regulation. The proposed method effectively solves the incompatibility problem between the simulator and the oximeter. The tests with the device also indicate that the correction factor could be quantitative for different kinds of pulse oximeters, if the calibration parameters can be achieved. The proposed correction method is simple to operate and suitable for the correction of different R value curves. It can provide certain technical support for the measurement verification of the blood oxygen module of the monitor of small brands. However, it should be noted that the attachment position, material, and thickness of the filter media will affect the correction effect. In conclusion, the proposed method of using an optical filter medium to modify the R value curve is a feasible correction method for the calibration of pulse oximeters. It has the potential to be applied to different kinds of pulse oximeters and could be of great value in the field of medical measurement.
- Lambert-Beer law /
- blood oxygen saturation /
- simulator /
- R value curve /
- verification

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图 1 透射式血氧仪测量原理示意图

Figure 1. Schematic diagram of transmission-type oximeter measurement principle

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图 2 光电容积脉搏波形成模型图

Figure 2. Schematic diagram of photoplethysmography (PPG) pulse wave formation model

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图 3 HbO₂与Hb摩尔消光系数图

Figure 3. Molar absorption coefficient diagram of HbO₂ and Hb

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图 4 模拟手指与监护仪指夹连接图

Figure 4. Schematic diagram of connection between simulated finger and monitor finger clip

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图 5 复印纸光谱曲线图

Figure 5. Spectrogram of photocopy paper

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表 1 不同R值曲线的血氧饱和度测量值

Table 1. Oxygen saturation measurements with different R value curves of the monitor

标准值（%）	Nellcor （%）	BCI （%）	Datascope （%）	Datex （%）	Masimo （%）
100	89	99	/	/	/
95	89	99	/	/	/
90	89	99	/	/	/
85	89	99	/	/	/
80	89	99	/	/	/
70	89	99	/	/	/
注：“/”表示未显示任何数值。

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表 2 加滤光介质后监护仪血氧模块测量值

Table 2. Measurement value of blood oxygen module of monitor after adding optical filter medium

标准值（%）	Nellcor （%）	BCI （%）	Datascope （%）	Datex （%）	Masimo （%）
100	100	100	100	100	100
95	95	95	94	95	95
90	90	91	89	91	92
85	84	86	83	84	85
80	79	81	78	78	80
70	72	71	65	67	69

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表 3 加滤光介质后监护仪血氧模块示值重复性

Table 3. Indication repeatability of blood oxygen module of monitor after adding optical filter medium

标准值（%）	R值曲线	被检监护仪测量值（%）						示值重复性（%）
100	Nellcor	100	100	100	100	100	100	0.0
90		90	90	91	90	91	91	0.5
70		71	72	71	71	72	71	0.5
100	BCI	100	100	100	100	100	100	0.0
90		91	91	90	90	91	91	0.5
70		72	71	71	72	72	72	0.5
100	Datascope	100	100	100	100	100	100	0.0
90		89	88	88	89	89	88	0.5
70		65	66	66	65	64	65	0.8
100	Datex	100	100	100	100	100	100	0.0
90		91	92	92	91	92	91	0.5
70		67	68	67	67	68	68	0.5
100	Masimo	100	100	100	100	100	100	0.0
90		92	92	93	93	93	93	0.5
70		69	69	70	69	69	71	0.8

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