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头发中药物残留分析技术的研究进展

韦棋 苏福海

韦棋,苏福海. 头发中药物残留分析技术的研究进展[J]. 计量科学与技术,2023, 67(5): 16-22, 30 doi: 10.12338/j.issn.2096-9015.2023.0103
引用本文: 韦棋,苏福海. 头发中药物残留分析技术的研究进展[J]. 计量科学与技术,2023, 67(5): 16-22, 30 doi: 10.12338/j.issn.2096-9015.2023.0103
WEI Qi, SU Fuhai. Advancements in Drug Residue Analysis Techniques in Hair[J]. Metrology Science and Technology, 2023, 67(5): 16-22, 30. doi: 10.12338/j.issn.2096-9015.2023.0103
Citation: WEI Qi, SU Fuhai. Advancements in Drug Residue Analysis Techniques in Hair[J]. Metrology Science and Technology, 2023, 67(5): 16-22, 30. doi: 10.12338/j.issn.2096-9015.2023.0103

头发中药物残留分析技术的研究进展

doi: 10.12338/j.issn.2096-9015.2023.0103
基金项目: 国家重点研发计划 ( 2018YFC0807301-4)。
详细信息
    作者简介:

    韦棋 ( 1995-),中国计量科学研究院研究实习员,研究方向:有机化学计量,邮箱:weiqi@nim.ac.cn

    通讯作者:

    苏福海( 1976-) ,中国计量科学研究院副研究员,研究方向:有机分析,邮箱:sufh@nim.ac.cn

  • 中图分类号: TB99

Advancements in Drug Residue Analysis Techniques in Hair

  • 摘要: 与其他生物样本相比,头发检测的主要优势在于检测窗口更宽。头发分析的前处理过程要比常规基质更加繁琐,主要包括采样、清洗、水解和提取净化等。用于头发中药物分析的方法主要有免疫分析法、色谱法、气相色谱/串联质谱法(GC-MS/MS)、液相色谱/串联质谱法(LC-MS/MS)等,因其高灵敏度和高选择性,GC-MS/MS和LC-MS/MS是头发中药物分析技术常用的分析方法。头发分析可提供药物成瘾史或药物毒性的相关信息,是法庭科学领域研究的热点之一,目前头发基质标准物质的相关研究较少,主要集中在违禁药物领域。回顾了过去几十年的相关研究,介绍了头发中药物分析技术和相关标准物质的研究进展。通过查阅相关文献,从头发中药物分析技术的特点、前处理过程、分析方法、应用以及相关标准物质的研究现状五个方面,对头发中药物分析技术和相关标准物质的研究进展进行综述。
  • 图  1  药物进入头发的途径

    Figure  1.  Pathway of drug entry into hair

    图  2  头发分析的前处理过程

    Figure  2.  Pre-treatment process in hair analysis

    图  3  头发分析的工作流程

    Figure  3.  Workflow of hair analysis

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出版历程
  • 收稿日期:  2023-04-07
  • 录用日期:  2023-04-10
  • 修回日期:  2023-05-22
  • 网络出版日期:  2023-07-24
  • 刊出日期:  2023-05-31

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