全氟和多氟烷基物质标准物质的应用与研制进展

朱欣; 韦棋; 苏福海

doi:10.12338/j.issn.2096-9015.2024.0181

全氟和多氟烷基物质标准物质的应用与研制进展

doi: 10.12338/j.issn.2096-9015.2024.0181

中国计量科学研究院，北京 100029

基金项目: NQI专项《饮用水全流程新污染物计量技术研发与标准物质研制》（2022YFF0609101）。

详细信息

作者简介:
朱欣（2001-），中国计量科学研究院硕士研究生，研究方向：有机化学计量，邮箱：jadezhlb22@163.com

通讯作者:
苏福海（1976- ），中国计量科学研究院副研究员，研究方向：有机分析，邮箱：sufh@nim.ac.cn

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出版历程
- 收稿日期: 2024-06-03
- 录用日期: 2024-07-26
- 修回日期: 2024-07-04
- 网络出版日期: 2024-09-04

Utilization and Advancement in Reference Materials of Per- and Polyfluoroalkyl Substances

National Institute of Metrology, Beijing 100029, China

摘要

摘要: 全氟和多氟烷基类物质（PFAS）是一类具有难降解性、生物累积性和长距离迁移性的持久性有机污染物，2023年开始，中国、美国和欧盟均已采取了一系列有力措施对其进行监管。标准物质作为PFAS监管有效性的重要组成，需要得到充分重视。目前我国PFAS标准物质体系存在一定不足，无论是纯物质和标准溶液，还是同位素标记标准物质和基体标准物质都需要进一步丰富和研制。综述了近5年来一些PFAS标准物质在环境分析中的应用，为环境分析和监测的工作者提供一些标准物质新颖的用法，并为我国PFAS标准物质体系建设提供了建议。
- 计量学 /
- 全氟和多氟烷基物质(PFAS) /
- 标准物质 /
- 基体标准物质
Abstract: Per- and polyfluoroalkyl substances (PFAS) are a class of persistent organic pollutants, which are difficult to degrade, bioaccumulative, and have long-range transport properties. Therefore, China, America and the EU have taken a series of legal measures to regulate PFAS since 2023. Reference materials play an important role PFAS regulation and should be given sufficient attention. Currently, the PFAS reference materials system in China is deficient, because not only pure substances and standard solutions, but also isotopically labeled reference substances materials and matrix reference materials need to be further enriched and developed. In addition, this paper reviews the application of some PFAS reference materials in environmental analysis in the past five years, providing underutilized uses for reference materials for environmental analysis and monitoring work. Finally, some suggestions are provided for the construction of the PFAS reference materials system in China.
- metrology /
- per- and polyfluoroalkyl substances(PFAS) /
- reference materials /
- matrix reference materials

HTML全文

表 1 一些含PFAS的基体标准物质作基体匹配材料的应用实例

Table 1. Some Applications of Matrix Reference Substances Containing PFAS as Matrix-Matched Materials

代号/Code	名称/Name	代表基体/Represented Matrix	参考文献/Reference
SRM 1950	Metabolites in Frozen Human Plasma	血浆	[35]
SRM 971a	Hormones in Frozen Human Serum	血清	[35]
BCR 461	Clay (F)	土壤	[36]
SRM 2585	Organic Contaminants in House Dust	土壤
SRM 2781	Domestic Sludge	土壤
IRMM 427	Pike-perch (PFASs in fish tissue)	鱼肉	[24]

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表 2 中国的全氟及多氟烷基类物质PFAS标准物质

Table 2. PFAS Reference Materials in China

名称/Name	编号/Code	分析物/Analytes	浓度水平/ Concentration Level
甲醇中全氟丁基磺酸钾溶液标准物质	GBW(E)084741	全氟丁基磺酸	50.5±2 µg/mL
甲醇中全氟丁基磺酸钾溶液标准物质	GBW(E)084742	全氟丁基磺酸	10.5±4 µg/mL
鱼肉粉中全氟辛基磺酸盐成分分析标准物质	GBW(E)100739	PFSAs：全氟辛基磺酸盐总和	1.40±0.17 µg/kg
鱼肉粉中9种全氟化合物成分分析标准物质	GBW(E)100740	PFCAs：全氟辛酸、全氟壬酸、全氟癸酸、全氟十一酸、全氟十二酸、全氟十四酸（C = 8-12, 14） PFSAs：全氟丁基磺酸盐、全氟己基磺酸盐、全氟辛基磺酸盐（C = 4, 6, 8）	3.45 - 6.41 µg/kg
鱼肉粉中全氟烷基化合物成分分析标准物质	GBW(E)100844	PFCAs：全氟辛酸、全氟壬酸、全氟癸酸、全氟十一酸、全氟十二酸（C = 8-12） PFSAs：全氟辛基磺酸盐总和	4.11 - 6.04 µg/kg
鱼肉粉中全氟烷基化合物成分分析标准物质	GBW(E)100845	PFCAs：全氟辛酸、全氟壬酸、全氟癸酸、全氟十一酸、全氟十二酸（C = 8-12） PFSAs：全氟辛基磺酸盐总和	24.6 - 29.8 µg/kg
1. PFCA：全氟烷基羧酸类物质；PFSA：全氟烷基磺酸类物质（以磺酸根计）。 2. C = ：指烷基链上碳的数目。

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表 3 NIST在售的全氟及多氟烷基类物质分析用标准物质

Table 3. Reference substances for PFAS sold by NIST

编号/Code	名称/ Description	分析物/Analytes	浓度水平/Concentration Level
SRM 1936	Great Lakes Sediment	PFOS (C = 8)	µg/kg
SRM 1947	Lake Michigan Fish Tissue	PFCA：C = 9, 10, 11, 13 PFSA：C = 8	µg/kg
SRM 1950	Metabolites in Frozen Human Plasma	PFCA：C = 8, 9, 10, 11 PFSA：C = 6, 8	µg/kg
SRM 1957	Organic Contaminants in Non-Fortified Human Serum (Freeze-Dried)	PFCA：C = 7, 8, 9, 10, 11 PFSA：C = 6, 8	µg/kg
SRM 1958	Organic Contaminants in Fortified Human Serum (Freeze-Dried)	PFCA：C = 8, 9 PFSA：C = 6, 8	µg/kg
SRM 2585	Organic Contaminants in House Dust	PFCA：C = 4, 6, 7, 9, 12, 13 PFSA：C = 6, 8	µg/kg
SRM 2586	Trace Elements in Soil Containing Lead from Paint (Nominal 500 mg/kg Lead)	PFSA：C = 8	µg/kg
SRM 2781	Domestic Sludge	PFCA：C = 6, 7, 8 PFSA：C = 6, 8 其他：PFOSA¹	µg/kg
SRM 8446	Perfluorinated Carboxylic Acids and Perfluorooctane Sulfonamide in Methanol	PFCA：C = 4-14 其他：PFOSA	mg/kg
SRM 8447	Perfluorinated Sulfonic Acids in Methanol	PFSA：C = 4, 6, 8	mg/kg
SRM 8690	PFAS in Aqueous Film-Forming Foams (AFFF) Formulation I	PFCA：C = 4, 6, 7, 8 PFSA：C = 3-7 其他：PFOSA, PFHxSA²	mg/kg
SRM 8691	PFAS in Aqueous Film-Forming Foams (AFFF) Formulation II	PFCA：C = 4, 6, 8 其他：PFOSA	µg/kg
SRM 8692	PFAS in Aqueous Film-Forming Foams (AFFF) Formulation III	PFCA：C = 4, 6 其他：PFOSA	µg/kg
SRM 8693	PFAS in Aqueous Film-Forming Foams (AFFF) Formulation IV	PFCA：C = 4, 6 其他：PFOSA	mg/kg
1. PFOSA：全氟辛烷磺胺酸 2. PFHxSA：全氟己烷磺胺酸

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表 4 LGC出售的部分全氟及多氟烷基类物质分析用标准物质

Table 4. Some Reference substances for PFAS sold by LGC

编号/Code	名称/ Description	分析物数目 /Count of Analytes	浓度水平 / Concentration Level
DRE-A30000051MW	EU Drinking Water Directive PFAS Mixture 10 μg/mL in Methanol:Water	20	µg/mL
DRE-A50000751MW	EPA Method 533 PFAS Mixture 10 μg/mL in Methanol:Water	22	µg/mL
DRE-A50000754MW	UCMR5 PFAS Mixture 10 μg/mL in Methanol:Water	29	µg/mL
DRE-A50000752MW	EPA Method 8327 PFAS Mixture 10 μg/mL in Methanol:Water	22	µg/mL
DRE-GS09000218MW	PFAA Mixture 218 100 μg/mL in Methanol:Water 96%:4%	11	µg/mL
DRE-A50000647MW	PFASiMix 100 μg/mL in Methanol:Water (96:4)	27	µg/mL
DRE-A50000152MW	EPA Method 537.1 PFAS Mixture 152 100 μg/mL in Methanol:Water (96:4)	18	µg/mL
IRMM-428	Water (PFAS in water)	7	ng/L

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