Mass Spectrometry Matrix Effect Study for the Trace Analysis of Chloramphenicol Residues in Honey

Organic isotope dilution mass spectrometry (IDMS) is a potential reference method for the accurate measurement of trace components in complex matrix samples. However, the analytical conditions, isotope dilution reagents, matrix effects (MEs), and other factors can also affect the results. In this paper, jujube and wattle honey were used as the study samples to compare the MEs in the trace measurement of chloramphenicol residues in honey under different extraction methods, so as to investigate the influence of MEs on the results, the compensation and elimination methods of MEs.