Preparation Process and Uniformity Analysis of a PET/CT Medical 68Ge-68Ga Phantom
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XIAO Yang,
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FAN Fuyou,
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LIU Haoran,
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CHU Taiwei,
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WANG Qian,
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LI Mengfei,
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ZHANG Jian,
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MOU Tiantian,
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YUN Mingkai,
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ZHANG Xiaoli,
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JIN Sunjun,
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LIANG Juncheng
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Graphical Abstract
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Abstract
68Ge-68Ga phantoms are mainly used in PET/CT image uniformity adjustment and SUV value correction. In order to produce a 68Ge-68Ga phantom, an epoxy resin modified by polysulfide rubber was used as the substrate and the carrier solution of 68Ge-68Ga was used to simulate 68Ge-68Ga radioactive solution. The homogeneous mixture of carrier solution, epoxy resin, and curing agent was filled in a shell of high density polyethylene (HDPE). After the mixture was solidified completely, a non-radioactive phantom with hard texture, color transparent and non-bubble was prepared. Inductively coupled plasma-optical emission spectrometer (ICP-OES) was used to detect the concentration of Ge and Ga elements in the phantom. The results of uniformity analysis showed that there was no significant difference in the concentration distribution of Ge and Ga in the phantom, and the relative standard deviations were 2.20% and 3.65%, respectively, which were equivalent to similar imported products. It was indicated that the process described in this paper can be used for the preparation of 68Ge-68Ga phantom.
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