Development and Uncertainty Evaluation of Reference Material of Caffeine Solution in Methanol-Water

LIU Shuhua; ZHANG Yiwen; WU Hong; ZHAO Haibo

doi:10.12338/j.issn.2096-9015.2021.0027

Volume 65 Issue 7

Jul. 2021

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LIU Shuhua, ZHANG Yiwen, WU Hong, ZHAO Haibo. Development and Uncertainty Evaluation of Reference Material of Caffeine Solution in Methanol-Water[J]. Metrology Science and Technology, 2021, 65(7): 28-33. doi: 10.12338/j.issn.2096-9015.2021.0027

Citation:

LIU Shuhua, ZHANG Yiwen, WU Hong, ZHAO Haibo. Development and Uncertainty Evaluation of Reference Material of Caffeine Solution in Methanol-Water[J]. Metrology Science and Technology, 2021, 65(7): 28-33. doi: 10.12338/j.issn.2096-9015.2021.0027

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Development and Uncertainty Evaluation of Reference Material of Caffeine Solution in Methanol-Water

doi: 10.12338/j.issn.2096-9015.2021.0027

Beijing Institute of Metrology, Beijing 100026, China

Available Online: 2021-06-09
Publish Date: 2021-07-16

Abstract

Abstract

The reference material of caffeine in methanol-water for LC-MS calibration was developed, and uncertainty was evaluated. Using pure caffeine, chromatographic grade methanol, and laboratory first-grade water as raw materials, the purity of the pure caffeine product was verified by the mass balance method, and the standard method weight-volume method was used to prepare the reference material of the caffeine solution in methanol with a concentration of 9.94 mg/L. Liquid chromatography was used to compare the value of the 9.94 mg/L standard solutions of caffeine in methanol with the national certified reference material GBW(E)130453, and the uniformity, short-term stability, and long-term stability of the solution were studied. The results show that the developed 9.94 mg/L reference material of caffeine in methanol-water has good uniformity and stability, with a relative extended uncertainty of 2% (k=2) and a validity period of 12 months.
- caffeine,
- LC-MS calibration,
- standard solution,
- uncertainty

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References(19)

References

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