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LI Shuo, ZHANG Nan, LIU Zhe, LI Qingwu, LI Li, WANG Haiyan, SUN Lei, ZHANG Zhengdong. Development of a Certified Reference Material of Alpha-Arbutin[J]. Metrology Science and Technology. doi: 10.12338/j.issn.2096-9015.2021.0595
Citation: LI Shuo, ZHANG Nan, LIU Zhe, LI Qingwu, LI Li, WANG Haiyan, SUN Lei, ZHANG Zhengdong. Development of a Certified Reference Material of Alpha-Arbutin[J]. Metrology Science and Technology. doi: 10.12338/j.issn.2096-9015.2021.0595

Development of a Certified Reference Material of Alpha-Arbutin

doi: 10.12338/j.issn.2096-9015.2021.0595
  • Accepted Date: 2022-03-31
  • Available Online: 2022-04-13
  • High purity α-arbutin reagent was used as raw material which was further identified and confirmed by MS/MS, IR, UV-vis, nuclear magnetic resonance, melting point, optical rotation, etc.. The chromatographic purity of α-arbutin reference standard was determined by high performance liquid chromatography (HPLC) coupled with fluorescence detector (FLD). Moisture and ignition residue determination were carried out according to the guideline specified in Volume IV of the Pharmacopoeia of the People's Republic of China 2020 Edition, respectively. The residual solvents were determined according to the procedure specified in the Safety and Technical Standards for Cosmetics. The purity of α-arbutin reference standard was then calculated by mass balance method and the certified value of α-arbutin is 99.87% with an expanded uncertainty of 2.46% (k=2). Homogeneity and stability tests were carried out with HPLC-FLD after packaging. The α-arbutin reference standard with a high purity, accurate value and stability can provide technical support to cosmetics quality and safety tests in China.
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