Volume 66 Issue 9
Sep.  2022
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WANG Xuxin, LI Xiaomin, ZHANG Qinghe. Uncertainty Evaluation of Different Quantitative Calibration Methods for the Determination of Vitamin B12 in Infant Formula[J]. Metrology Science and Technology, 2022, 66(9): 23-27, 46. doi: 10.12338/j.issn.2096-9015.2022.0089
Citation: WANG Xuxin, LI Xiaomin, ZHANG Qinghe. Uncertainty Evaluation of Different Quantitative Calibration Methods for the Determination of Vitamin B12 in Infant Formula[J]. Metrology Science and Technology, 2022, 66(9): 23-27, 46. doi: 10.12338/j.issn.2096-9015.2022.0089

Uncertainty Evaluation of Different Quantitative Calibration Methods for the Determination of Vitamin B12 in Infant Formula

doi: 10.12338/j.issn.2096-9015.2022.0089
  • Available Online: 2022-09-06
  • Publish Date: 2022-09-30
  • In this study, take measurement of the vitamin B12 in infant formula as an example, measurement uncertainty was evaluated through four calibration methods, including standard addition method, standard addition-isotope dilution mass spectrometry method, single point isotope dilution mass spectrometry method, and standard calibration curve isotope dilution mass spectrometry method. The uncertainty evaluation of the four quantitative methods was assessed based on the ISO-GUM guidelines and other uncertainty assessment methods. The uncertainties introduced by the method of repeatability and curve fitting were the primary sources of uncertainty. Furthermore, the uncertainties obtained by the standard addition method were significantly more significant than those obtained by the isotope internal standard method. The comparative study of different quantification methods can lead to a more effective selection of quantification methods and improved measurement accuracy.
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  • [1]
    国家质量监督检验检疫总局. 测量不确定度评定与表示: JJF1059.1-2012[S]. 北京: 中国质检出版社, 2013.
    [2]
    DJELLOULI O, ROZET E, DAHMANI B, et al. Compromise in uncertainty estimation by modelling and validation approaches for an HPLC-UV method for measurement of biochemical indicators of vitamins A and E[J]. Analyst, 2018, 143(6): 1492-1501. doi: 10.1039/C7AN01804E
    [3]
    KIM J M, CHOI S H, SHIN G H, et al. Method validation and measurement uncertainty for the simultaneous determination of synthetic phenolic antioxidants in edible oils commonly consumed in Korea[J]. Food Chem, 2016, 213: 19-25. doi: 10.1016/j.foodchem.2016.06.053
    [4]
    LI Y, GILL B D, GRAINGER M N C, et al. The analysis of vitamin B12 in milk and infant formula: A review[J]. Int Dairy J, 2019, 99: 104543. doi: 10.1016/j.idairyj.2019.104543
    [5]
    LI X Q, YANG Z, ZHANG Q H, et al. Evaluation of matrix effect in isotope dilution mass spectrometry based on quantitative analysis of chloramphenicol residues in milk powder[J]. Anal Chim Acta, 2014, 807: 75-83. doi: 10.1016/j.aca.2013.11.017
    [6]
    RAPOSO F, BARCELÓ D. Challenges and strategies of matrix effects using chromatography-mass spectrometry: An overview from research versus regulatory view points[J]. TrAC Trend Anal Chem, 2021, 134: 116068. doi: 10.1016/j.trac.2020.116068
    [7]
    BIENVENU JF, PROVENCHER G, BELANGER P, et al. Standardized Procedure for the Simultaneous Determination of the Matrix Effect, Recovery, Process Efficiency, and Internal Standard Association[J]. Anal Chem, 2017, 89(14): 7560-7568. doi: 10.1021/acs.analchem.7b01383
    [8]
    MARTINS ML, RIZZETTI TM, KEMMERICH M, et al. Dilution standard addition calibration: A practical calibration strategy for multiresidue organic compounds determination[J]. J Chromatogr A, 2016, 1460: 84-91. doi: 10.1016/j.chroma.2016.07.013
    [9]
    PÉREZ-FERNÁNDEZ V, GENTILI A, MARTINELLI A, et al. Evaluation of oxidized buckypaper as material for the solid phase extraction of cobalamins from milk: Its efficacy as individual and support sorbent of a hydrophilic-lipophilic balance copolymer[J]. J Chromatogr A, 2016, 1428: 255-266. doi: 10.1016/j.chroma.2015.07.109
    [10]
    ZIRONI E, GAZZOTTI T, BARBAROSSA A, et al. Technical note: development and validation of a method using ultra performance liquid chromatography coupled with tandem mass spectrometry for determination of vitamin B12 concentrations in milk and dairy products[J]. J Dairy Sci, 2013, 96(5): 2832-2836. doi: 10.3168/jds.2012-6451
    [11]
    LUO X, CHEN B, DING L, et al. HPLC-ESI-MS analysis of Vitamin B12 in food products and in multivitamins-multimineral tablets[J]. Anal Chim Acta, 2006, 562(2): 185-189. doi: 10.1016/j.aca.2006.01.073
    [12]
    LIM YO, KIM B, AHN S, et al. Improvement of accuracy for the determination of vitamin A in infant formula by isotope dilution-liquid chromatography/tandem mass spectrometry[J]. Food Chem, 2011, 126(3): 1393-1398. doi: 10.1016/j.foodchem.2010.11.118
    [13]
    SHEHATA AB, RIZK MS, FARAG AM, et al. Development of two reference materials for all trans-retinol, retinyl palmitate, alpha- and gamma-tocopherol in milk powder and infant formula[J]. J Food Drug Anal, 2015, 23(1): 82-92. doi: 10.1016/j.jfda.2014.10.004
    [14]
    LEE J, JANG ES, KIM B. Development of isotope dilution-liquid chromatography/mass spectrometry combined with standard addition techniques for the accurate determination of tocopherols in infant formula[J]. Anal Chim Acta, 2013, 787: 132-139. doi: 10.1016/j.aca.2013.05.034
    [15]
    ISO. Guide to the Expression of Uncertainty in Measurement: ISO 1993 (E)[S]. ISO, 1993.
    [16]
    中国合格评定国家认可委员会. 化学分析中不确定度的评估指南: CNAS-GL006[S]. 北京: 中国计量出版社, 2019.
    [17]
    孔祥明, 魏晓琴. 不同定量方法对蔬菜农药残留测量不确定度的影响研究[J]. 宁夏农林科技, 2020, 61(11): 34-37.
    [18]
    田甜, 刘书妤, 张燕, 等. 蜂蜜中氯霉素痕量残留测量质谱基质效应研究[J]. 计量科学与技术, 2021, 65(5): 77-82,100. doi: 10.12338/j.issn.2096-9015.2020.9037
    [19]
    LIM S, YUN C I, KO K Y, et al. Validation and measurement uncertainty of HPLC method for simultaneous determination of 10 dyes in adulterated Phellodendron[J]. Korean J Food Sci Technol, 2021, 53(4): 391-399.
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