Volume 67 Issue 1
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GAO Tianheng, REN Tongxiang, WANG Song. Research Progress in Quantitative Analysis of Soft Samples Based on LA-ICP-MS[J]. Metrology Science and Technology, 2023, 67(1): 29-38, 67. doi: 10.12338/j.issn.2096-9015.2022.0269
Citation: GAO Tianheng, REN Tongxiang, WANG Song. Research Progress in Quantitative Analysis of Soft Samples Based on LA-ICP-MS[J]. Metrology Science and Technology, 2023, 67(1): 29-38, 67. doi: 10.12338/j.issn.2096-9015.2022.0269

Research Progress in Quantitative Analysis of Soft Samples Based on LA-ICP-MS

doi: 10.12338/j.issn.2096-9015.2022.0269
  • Available Online: 2023-02-04
  • Publish Date: 2023-01-18
  • Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) has gained significant attention in recent years due to its capability to directly analyze solid samples under quasi-nondestructive conditions, and to provide in-situ elemental concentration information with a certain spatial resolution. However, quantitative analysis of soft samples by LA-ICP-MS remains a challenge due to elemental fractionation and complex matrix effects. To obtain reliable and comparable results, the corresponding measurement protocol not only requires the use of verified methods, but also the establishment of correct calibration methods based on standards, thus enabling the traceability of measurement results. This paper reviews relevant literature published by domestic and foreign research teams since 2000, and introduces the common measurement strategies of LA-ICP-MS for three different types of soft samples. By summarizing the verification parameters of the five methods, the current situation of quantitative methods is analyzed from three aspects: method precision, accuracy, and representativeness. The paper also highlights the problem of method traceability. The results show that the quantification strategy that matches the matrix and is synchronized with the measurement is more advantageous. However, the lack of a fully matrix-matched certified reference material (CRM) limits the research on sampling representativeness and traceability of measurement results. Therefore, these two aspects will be the key problems to be addressed in the future when using LA-ICP-MS to carry out quantitative analysis methods of soft samples. Although some researchers have conducted studies on the synthesis method of soft standard and the traceability of measurement results by isotope dilution method, there are still several issues that need to be resolved.
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  • [1]
    Hattendorf B, Latkoczy C, D Günther. Peer Reviewed: Laser Ablation-ICPMS[J]. Analytical Chemistry, 2003, 75(15): 341A-347A. doi: 10.1021/ac031283r
    MARTINEZ M, BAUDELET M. Calibration strategies for elemental analysis of biological samples by LA-ICP-MS and LIBS – A review[J]. Anal Bioanal Chem, 2020, 412(1): 27-36. doi: 10.1007/s00216-019-02195-1
    RUSSO R E, MAO X, LIU H, et al. Laser ablation in analytical chemistry—a review[J]. Talanta, 2002, 57(3): 425-451. doi: 10.1016/S0039-9140(02)00053-X
    FERNáNDEZ B, CLAVERIE F, PéCHEYRAN C, et al. Direct analysis of solid samples by fs-LA-ICP-MS[J]. Trends Anal Chem, 2007, 26(10): 951-966. doi: 10.1016/j.trac.2007.08.008
    GüNTHER D, HEINRICH C A. Comparison of the ablation behaviour of 266 nm Nd: YAG and 193 nm ArF excimer lasers for LA-ICP-MS analysis[J]. J Anal At Spectrom, 1999, 14(9): 1369-1374. doi: 10.1039/A901649J
    PISONERO J, GüNTHER D. Femtosecond laser ablation inductively coupled plasma mass spectrometry: Fundamentals and capabilities for depth profiling analysis[J]. Mass Spectrom Rev, 2008, 27(6): 609-623. doi: 10.1002/mas.20180
    STEHRER T, HEITZ J, PEDARNIG J D, et al. LA-ICP-MS analysis of waste polymer materials[J]. Anal Bioanal Chem, 2010, 398(1): 415-424. doi: 10.1007/s00216-010-3963-6
    SAJNóG A, HANĆ A, BARAŁKIEWICZ D. Metrological approach to quantitative analysis of clinical samples by LA-ICP-MS: A critical review of recent studies[J]. Talanta, 2018, 182: 92-110. doi: 10.1016/j.talanta.2018.01.050
    MILISZKIEWICZ N, WALAS S, TOBIASZ A. Current approaches to calibration of LA-ICP-MS analysis[J]. J Anal At Spectrom, 2015, 30(2): 327-338. doi: 10.1039/C4JA00325J
    TODOLı́ J L, MERMET J M. Study of polymer ablation products obtained by ultraviolet laser ablation — inductively coupled plasma atomic emission spectrometry[J]. Spectrochimica Acta Part B:Atomic Spectroscopy, 1998, 53(12): 1645-1656. doi: 10.1016/S0584-8547(98)00219-5
    FRICK D A, GüNTHER D. Fundamental studies on the ablation behaviour of carbon in LA-ICP-MS with respect to the suitability as internal standard[J]. J Anal At Spectrom, 2012, 27(8): 1294-1303. doi: 10.1039/c2ja30072a
    WU B, ZORIY M, CHEN Y, et al. Imaging of nutrient elements in the leaves of Elsholtzia splendens by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS)[J]. Talanta, 2009, 78(1): 132-137. doi: 10.1016/j.talanta.2008.10.061
    SYLVESTER P J. LA-(MC)-ICP-MS Trends in 2006 and 2007 with Particular Emphasis on Measurement Uncertainties[J]. Geostand Geoanal Res, 2008, 32(4): 469-488. doi: 10.1111/j.1751-908X.2008.00924.x
    TAYLOR A, DAY M P, HILL S, et al. Atomic spectrometry update: Review of advances in the analysis of clinical and biological materials, foods and beverages[J]. J Anal At Spectrom, 2014, 29(3): 386-426. doi: 10.1039/c4ja90001d
    VOSS M, NUNES M A G, CORAZZA G, et al. A new approach to calibration and determination of selected trace elements in food contact polymers by LA-ICP-MS[J]. Talanta, 2017, 170: 488-495. doi: 10.1016/j.talanta.2017.04.048
    KUCZELINIS F, PETERSEN J H, WEIS P, et al. Calibration of LA-ICP-MS via standard addition using dried picoliter droplets[J]. J Anal At Spectrom, 2020, 35(9): 1922-1931. doi: 10.1039/D0JA00184H
    REIFSCHNEIDER O, SCHüTZ C L, BROCHHAUSEN C, et al. Quantitative bioimaging of p-boronophenylalanine in thin liver tissue sections as a tool for treatment planning in boron neutron capture therapy[J]. Anal Bioanal Chem, 2015, 407(9): 2365-2371. doi: 10.1007/s00216-014-8012-4
    POZEBON D, DRESSLER V L, MESKO M F, et al. Bioimaging of metals in thin mouse brain section by laser ablation inductively coupled plasma mass spectrometry: novel online quantification strategy using aqueous standards[J]. J Anal At Spectrom, 2010, 25(11): 1739-1744. doi: 10.1039/c0ja00055h
    刘勇胜, 胡兆初, 李明, 等. LA-ICP-MS在地质样品元素分析中的应用[J]. Chin Sci Bull, 2013, 58(36): 3753-3769.
    AUSTIN C, FRYER F, LEAR J, et al. Factors affecting internal standard selection for quantitative elemental bio-imaging of soft tissues by LA-ICP-MS[J]. J Anal At Spectrom, 2011, 26(7): 1494-1501. doi: 10.1039/c0ja00267d
    PAN H, FENG L, LU Y, et al. Calibration strategies for laser ablation ICP-MS in biological studies: A review[J]. Trends Anal Chem, 2022, 156: 116710. doi: 10.1016/j.trac.2022.116710
    BEDSON P. Guidelines for achieving high accuracy in isotope dilution mass spectrometry (IDMS) [M]. Royal Society of Chemistry, 2002.
    KEMPENAERS L, BINGS N H, JEFFRIES T E, et al. The use of LA-ICP-MS for the characterization of the micro-heterogeneity of heavy metals in BCR CRM 680[J]. J Anal At Spectrom, 2001, 16(9): 1006-1011. doi: 10.1039/b102512k
    DOBNEY A M, MANK A J G, GROBECKER K H, et al. Laser ablation inductively coupled plasma mass spectrometry as a tool for studying heterogeneity within polymers[J]. Anal Chim Acta, 2000, 423(1): 9-19. doi: 10.1016/S0003-2670(00)01047-3
    MANS C, SIMONS C, HANNING S, et al. New polymeric candidate reference materials for XRF and LA-ICP-MS - development and preliminary characterization[J]. X-Ray Spectrom, 2009, 38(1): 52-57. doi: 10.1002/xrs.1120
    VILLASEñOR Á, BOCCONGELLI M, TODOLí J L. Quantitative elemental analysis of polymers through laser ablation – inductively coupled plasma by using a dried droplet calibration approach, DDCA[J]. J Anal At Spectrom, 2018, 33(7): 1173-1183. doi: 10.1039/C8JA00055G
    BONTA M, LIMBECK A. Metal analysis in polymers using tandem LA-ICP-MS/LIBS: eliminating matrix effects using multivariate calibration[J]. J Anal At Spectrom, 2018, 33(10): 1631-1637. doi: 10.1039/C8JA00161H
    MAKINO Y, NAKAZATO T. Determination of trace elements in polymers using fsLA-ICP-MS with internal standardization by carbon[J]. J Anal At Spectrom, 2021, 36(9): 1895-1899. doi: 10.1039/D1JA00198A
    THIELEKE J P, VOGT C. A calibration strategy for LA-ICP-MS using isotope dilution for solid reference materials[J]. J Anal At Spectrom, 2016, 31(6): 1198-1205. doi: 10.1039/C6JA00042H
    ŠALA M, ŠELIH V S, VAN ELTEREN J T. Gelatin gels as multi-element calibration standards in LA-ICP-MS bioimaging: fabrication of homogeneous standards and microhomogeneity testing[J]. Analyst, 2017, 142(18): 3356-3359. doi: 10.1039/C7AN01361B
    LI Y, GUO W, HU Z, et al. Method Development for Direct Multielement Quantification by LA-ICP-MS in Food Samples[J]. Journal of Agricultural and Food Chemistry, 2019, 67(3): 935-942. doi: 10.1021/acs.jafc.8b05479
    BECKER J S, ZORIY M V, PICKHARDT C, et al. Imaging of Copper, Zinc, and Other Elements in Thin Section of Human Brain Samples (Hippocampus) by Laser Ablation Inductively Coupled Plasma Mass Spectrometry[J]. Anal Chem, 2005, 77(10): 3208-3216. doi: 10.1021/ac040184q
    DOBROWOLSKA J, DEHNHARDT M, MATUSCH A, et al. Quantitative imaging of zinc, copper and lead in three distinct regions of the human brain by laser ablation inductively coupled plasma mass spectrometry[J]. Talanta, 2008, 74(4): 717-723. doi: 10.1016/j.talanta.2007.06.051
    HARE D J, RAVEN E P, ROBERTS B R, et al. Laser ablation-inductively coupled plasma-mass spectrometry imaging of white and gray matter iron distribution in Alzheimer's disease frontal cortex[J]. NeuroImage, 2016, 137: 124-131. doi: 10.1016/j.neuroimage.2016.05.057
    HACHMöLLER O, AICHLER M, SCHWAMBORN K, et al. Element bioimaging of liver needle biopsy specimens from patients with Wilson’s disease by laser ablation-inductively coupled plasma-mass spectrometry[J]. J Trace Elem Med Biol, 2016, 35: 97-102. doi: 10.1016/j.jtemb.2016.02.001
    HACHMöLLER O, ZIBERT A, ZISCHKA H, et al. Spatial investigation of the elemental distribution in Wilson’s disease liver after d-penicillamine treatment by LA-ICP-MS[J]. J Trace Elem Med Biol, 2017, 44: 26-31. doi: 10.1016/j.jtemb.2017.05.008
    GRIJALBA N, LEGRAND A, HOLLER V, et al. A novel calibration strategy based on internal standard–spiked gelatine for quantitative bio-imaging by LA-ICP-MS: application to renal localization and quantification of uranium[J]. Anal Bioanal Chem, 2020, 412(13): 3113-3122. doi: 10.1007/s00216-020-02561-4
    FENG L, WANG J, LI H, et al. A novel absolute quantitative imaging strategy of iron, copper and zinc in brain tissues by Isotope Dilution Laser Ablation ICP-MS[J]. Anal Chim Acta, 2017, 984: 66-75. doi: 10.1016/j.aca.2017.07.003
    DOUGLAS D N, O'REILLY J, O'CONNOR C, et al. Quantitation of the Fe spatial distribution in biological tissue by online double isotope dilution analysis with LA-ICP-MS: a strategy for estimating measurement uncertainty[J]. J Anal At Spectrom, 2016, 31(1): 270-279. doi: 10.1039/C5JA00351B
    WIENOLD J, RECKNAGEL S, SCHARF H, et al. Elemental analysis of printed circuit boards considering the ROHS regulations[J]. Waste Management, 2011, 31(3): 530-535. doi: 10.1016/j.wasman.2010.10.002
    SIMONS C, MANS C, HANNING S, et al. Study on microscopic homogeneity of polymeric candidate reference materials BAM H001-BAM H010 by means of synchrotron mu-XRF and LA-ICP-MS[J]. J Anal At Spectrom, 2010, 25(1): 40-43. doi: 10.1039/B917008A
    ZHOU J, NI X, FU J, et al. Quantitation and ImagingAnalysis of Biological Samples by LA-ICP-MS[J]. At Spectrosc, 2021, 42(4): 210-216.
    VAN HELDEN T, BRAEUER S, VAN ACKER T, et al. High-speed mapping of Hg and Se in biological tissue via laser ablation-inductively coupled plasma-mass spectrometry[J]. J Anal At Spectrom, 2022, 37(7): 1455-1461. doi: 10.1039/D2JA00131D
    ZHOU J, GUO W, JIN L, et al. Elemental Analysis of Solid Food Materials Using a Reliable LaserAblation Inductively Coupled Plasma Mass Spectrometry Method[J]. Journal of Agricultural and Food Chemistry, 2022, 70(15): 4765-4773. doi: 10.1021/acs.jafc.1c06262
    DEEGAN R D, BAKAJIN O, DUPONT T F, et al. Capillary flow as the cause of ring stains from dried liquid drops[J]. Nature, 1997, 389(6653): 827-829. doi: 10.1038/39827
    HU H, LARSON R G. Marangoni effect reverses coffee-ring depositions[J]. J Phys Chem B, 2006, 110(14): 7090-7094. doi: 10.1021/jp0609232
    ZORIY M V, BECKER J S. Imaging of elements in thin cross sections of human brain samples by LA-ICP-MS: A study on reproducibility[J]. Int J Mass spectrom, 2007, 264(2): 175-180.
    COSTAS-RODRíGUEZ M, VAN ACKER T, HASTUTI A A M B, et al. Laser ablation-inductively coupled plasma-mass spectrometry for quantitative mapping of the copper distribution in liver tissue sections from mice with liver disease induced by common bile duct ligation[J]. J Anal At Spectrom, 2017, 32(9): 1805-1812. doi: 10.1039/C7JA00134G
    NEUMANN B, HöSL S, SCHWAB K, et al. Multiplex LA-ICP-MS bio-imaging of brain tissue of a parkinsonian mouse model stained with metal-coded affinity-tagged antibodies and coated with indium-spiked commercial inks as internal standards[J]. J Neurosci Methods, 2020, 334: 108591. doi: 10.1016/j.jneumeth.2020.108591
    WESTERHAUSEN M T, LOCKWOOD T E, GONZALEZ DE VEGA R, et al. Low background mould-prepared gelatine standards for reproducible quantification in elemental bio-imaging[J]. Analyst, 2019, 144(23): 6881-6888. doi: 10.1039/C9AN01580A
    ZHENG L N, FENG L X, SHI J W, et al. Single-Cell Isotope Dilution Analysis with LA–ICP–MS: A New Approach for Quantification of Nanoparticles in Single Cells[J]. Anal Chem, 2020, 92(21): 14339-14345. doi: 10.1021/acs.analchem.0c01775
    MARTINEZ-LOPEZ C, TREJOS T, COULSON S, et al. Interlaboratory evaluations of the performance of elemental analytical methods for the forensic analysis and comparisons of electrical tapes[J]. Forensic Chemistry, 2019, 12: 66-77. doi: 10.1016/j.forc.2019.01.001
    MARTINEZ-LOPEZ C, SAKAYANAGI M, ALMIRALL J R. Elemental analysis of packaging tapes by LA-ICP-MS and LIBS[J]. Forensic Chemistry, 2018, 8: 40-48. doi: 10.1016/j.forc.2018.01.004
    VANDER PYL C, MARTINEZ-LOPEZ C, MENKING HOGGATT K, et al. Analysis of primer gunshot residue particles by laser induced breakdown spectroscopy and laser ablation inductively coupled plasma mass spectrometry[J]. Analyst, 2021, 146(17): 5389-5402. doi: 10.1039/D1AN00689D
    THOMPSON M, ELLISON S L, WOOD R. Harmonized guidelines for single-laboratory validation of methods of analysis (IUPAC Technical Report)[J]. Pure Appl Chem, 2002, 74(5): 835-855. doi: 10.1351/pac200274050835
    JUROWSKI K, BUSZEWSKI B, PIEKOSZEWSKI W. The analytical calibration in (bio)imaging/mapping of the metallic elements in biological samples – Definitions, nomenclature and strategies: State of the art[J]. Talanta, 2015, 131: 273-285. doi: 10.1016/j.talanta.2014.07.089
    PISONERO J, FERNáNDEZ B, GüNTHER D. Critical revision of GD-MS, LA-ICP-MS and SIMS as inorganic mass spectrometric techniques for direct solid analysis[J]. J Anal At Spectrom, 2009, 24(9): 1145-1160. doi: 10.1039/b904698d
    CARTER S, FISHER A, GARCIA R, et al. Atomic spectrometry update: review of advances in the analysis of metals, chemicals and functional materials[J]. J Anal At Spectrom, 2016, 31(11): 2114-2164. doi: 10.1039/C6JA90044E
    LOBO L, FERNáNDEZ B, MUñIZ R, et al. Capabilities of radiofrequency pulsed glow discharge-time of flight mass spectrometry for molecular screening in polymeric materials: positive versus negative ion mode[J]. J Anal At Spectrom, 2016, 31(1): 212-219. doi: 10.1039/C5JA00291E
    JERŠE A, MERVIČ K, VAN ELTEREN J T, et al. Quantification anomalies in single pulse LA-ICP-MS analysis associated with laser fluence and beam size[J]. Analyst, 2022, 147(23): 5293-5299. doi: 10.1039/D2AN01172G
    VAN ELTEREN J T, ŠELIH V S, ŠALA M. Insights into the selection of 2D LA-ICP-MS (multi)elemental mapping conditions[J]. J Anal At Spectrom, 2019, 34(9): 1919-1931. doi: 10.1039/C9JA00166B
    MICHALISZYN L, REN T, RöTHKE A, et al. A new method for the SI-traceable quantification of element contents in solid samples using LA-ICP-MS[J]. J Anal At Spectrom, 2020, 35(1): 126-135. doi: 10.1039/C9JA00296K
    吴雪, 薄梦, 孙晓璟, 等. 液相色谱-质谱法检测甲磺酸沙非胺中基因毒性杂质[J]. 计量科学与技术, 2022, 66(11): 27-30.
    易可可, 谢洁, 龚晓云, 等. 液相色谱-串联质谱应用研究进展[J]. 计量科学与技术, 2021(2): 7-15, 6.
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