Volume 67 Issue 5
May  2023
Turn off MathJax
Article Contents
WEI Qi, SU Fuhai. Advancements in Drug Residue Analysis Techniques in Hair[J]. Metrology Science and Technology, 2023, 67(5): 16-22, 30. doi: 10.12338/j.issn.2096-9015.2023.0103
Citation: WEI Qi, SU Fuhai. Advancements in Drug Residue Analysis Techniques in Hair[J]. Metrology Science and Technology, 2023, 67(5): 16-22, 30. doi: 10.12338/j.issn.2096-9015.2023.0103

Advancements in Drug Residue Analysis Techniques in Hair

doi: 10.12338/j.issn.2096-9015.2023.0103
  • Received Date: 2023-04-07
  • Accepted Date: 2023-04-10
  • Rev Recd Date: 2023-05-22
  • Available Online: 2023-07-24
  • Publish Date: 2023-05-31
  • Compared to other biological samples, hair offers an extended window for drug detection. The pre-treatment process in hair analysis is notably more complex than standard matrices, involving procedures such as sampling, cleaning, hydrolysis, and extraction purification. Techniques employed for drug residue analysis in hair encompass immunoassays, chromatographic methods, gas chromatography-tandem mass spectrometry (GC-MS/MS), and liquid chromatography-tandem mass spectrometry (LC-MS/MS). Owing to their high sensitivity and selectivity, GC-MS/MS and LC-MS/MS serve as the prevalent methods for drug analysis in hair. Hair analysis can furnish information pertaining to a history of drug addiction or drug toxicity, making it a subject of keen interest in forensic science research. Presently, research related to hair matrix standard materials is rather sparse, predominantly concentrating on prohibited drugs. This article reviews the development over the past few decades in hair drug analysis techniques and related standard materials. By examining the relevant literature, this review presents an overview of the research progress in hair drug analysis techniques and associated reference materials, focusing on their characteristics, pre-treatment processes, analytical methods, applications, and the current state of related reference material research.
  • loading
  • [1]
    KINTZ P. Hair Analysis in Forensic Toxicology: An Updated Review with a Special Focus on Pitfalls [J]. Curr Pharm Des, 2017, 23(36): 5480-5486.
    [2]
    GRATACÓS-CUBARSÍ M, CASTELLARI M, VALERO A, et al. Hair analysis for veterinary drug monitoring in livestock production [J]. J Chromatogr B Analyt Technol Biomed Life Sci, 2006, 834(1-2): 14-25. doi: 10.1016/j.jchromb.2006.03.007
    [3]
    LOZANO I, SAUNIER JB, PANHARD S, et al. The diversity of the human hair colour assessed by visual scales and instrumental measurements[J]. Int J Cosmet Sci, 2017, 39(1): 101-107. doi: 10.1111/ics.12359
    [4]
    KHAJURIA H, NAYAK BP, BADIYE A. Toxicological hair analysis: Pre-analytical, analytical and interpretive aspects[J]. Med Sci Law, 2018, 58(3): 137-146. doi: 10.1177/0025802418768305
    [5]
    李军. 毛发中常见毒品分析的研究进展[J]. 铁道警察学院学报, 2017, 27(4): 60-64. doi: 10.3969/j.issn.1009-3192.2017.04.012
    [6]
    CONE EJ, YOUSEFNEJAD D, DARWIN WD, et al. Testing human hair for drugs of abuse. II. Identification of unique cocaine metabolites in hair of drug abusers and evaluation of decontamination procedures [J]. J Anal Toxicol, 1991, 15(5): 250-255. doi: 10.1093/jat/15.5.250
    [7]
    MANTINIEKS D, GEROSTAMOULOS D, WRIGHT P, et al. The effectiveness of decontamination procedures used in forensic hair analysis[J]. Forensic Sci Med Pathol, 2018, 14(3): 349-357. doi: 10.1007/s12024-018-9994-6
    [8]
    KINTZ P, CIRIMELE V, SACHS H, et al. Testing for anabolic steroids in hair from two bodybuilders[J]. Forensic Sci Int, 1999, 101(3): 209-216. doi: 10.1016/S0379-0738(99)00024-9
    [9]
    SPRINGFIELD AC, CARTMELL LW, AUFDERHEIDE AC, et al. Cocaine and metabolites in the hair of ancient Peruvian coca leaf chewers[J]. Forensic Sci Int, 1993, 63(1-3): 269-275. doi: 10.1016/0379-0738(93)90280-N
    [10]
    SHIMA N, SASAKI K, KAMATA T, et al. Hair Testing for Drugs in the Field of Forensics[J]. Yakugaku Zasshi, 2019, 139(5): 705-713. doi: 10.1248/yakushi.18-00166-4
    [11]
    杨洪国, 李重阳, 丁斌. 毒品与毛发的结合及其影响因素[J]. 中国司法鉴定, 2013 (1): 46-49. doi: 10.3969/j.issn.1671-2072.2013.01.008
    [12]
    KINTZ P, CIRIMELE V, LUDES B. Pharmacological criteria that can affect the detection of doping agents in hair[J]. Forensic Sci Int, 2000, 107(1-3): 325-334. doi: 10.1016/S0379-0738(99)00176-0
    [13]
    COOPER GA, KRONSTRAND R, KINTZ P. Society of Hair Testing. Society of Hair Testing guidelines for drug testing in hair[J]. Forensic Sci Int, 2012, 218(1-3): 20-24. doi: 10.1016/j.forsciint.2011.10.024
    [14]
    PRAGST F, BALIKOVA MA. State of the art in hair analysis for detection of drug and alcohol abuse[J]. Clin Chim Acta, 2006, 370(1-2): 17-49. doi: 10.1016/j.cca.2006.02.019
    [15]
    KRONSTRAND R, FöRSTBERG-PETERSON S, KåGEDAL B, et al. Codeine concentration in hair after oral administration is dependent on melanin content[J]. Clin Chem, 1999, 45(9): 1485-1494. doi: 10.1093/clinchem/45.9.1485
    [16]
    HENDERSON GL. Mechanisms of drug incorporation into hair[J]. Forensic Sci Int, 1993, 63(1-3): 19-29. doi: 10.1016/0379-0738(93)90256-A
    [17]
    TESTORF MF, KRONSTRAND R, SVENSSON SP, et al. Characterization of [3H] flunitrazepam binding to melanin[J]. Anal Biochem, 2001, 298(2): 259-264. doi: 10.1006/abio.2001.5364
    [18]
    KINTZ P. Issues about axial diffusion during segmental hair analysis[J]. Ther Drug Monit, 2013, 35(3): 408-410. doi: 10.1097/FTD.0b013e318285d5fa
    [19]
    WADA M, IKEDA R, KURODA N, et al. Analytical methods for abused drugs in hair and their applications[J]. Anal Bioanal Chem, 2010, 397(3): 1039-1067. doi: 10.1007/s00216-010-3569-z
    [20]
    WELCH MJ, SNIEGOSKI LT, ALLGOOD CC, et al. Hair analysis for drugs of abuse: evaluation of analytical methods, environmental issues, and development of reference materials[J]. J Anal Toxicol, 1993, 17(7): 389-398. doi: 10.1093/jat/17.7.389
    [21]
    LEE S, PARK Y, KIM J, et al. Feasibility of rat hair as a quality control material for the determination of methamphetamine and amphetamine in human hair[J]. Arch Pharm Res, 2011, 34(4): 593-598. doi: 10.1007/s12272-011-0409-4
    [22]
    孟梁, 臧祥日, 申贵隽, 等. 毛细管区带电泳同时检测人尿和头发中6种毒品[J]. 分析化学, 2010, 38(10): 1474-1478.
    [23]
    宋爱英, 康明星, 杨晶, 等. 固相微萃取在苯丙胺类毒品分析中的应用[J]. 中国法医学杂志, 2018, 33(6): 604-607. doi: 10.13618/j.issn.1001-5728.2018.06.011
    [24]
    孙英英, 沈敏. 固相微萃取技术在毛发药物分析中的应用[J]. 中国司法鉴定, 2010(3): 27-32, 51. doi: 10.3969/j.issn.1671-2072.2010.03.007
    [25]
    吴雪, 薄梦, 孙晓璟, 等. 液相色谱-质谱法检测甲磺酸沙非胺中基因毒性杂质[J]. 计量科学与技术, 2022, 66(11): 27-30. doi: 10.12338/j.issn.2096-9015.2021.0632
    [26]
    张晓非. 微珠萃取技术的研究及在毒物毒品分析中的应用[D]. 长春: 长春理工大学, 2011.
    [27]
    ALY AA, GÓRECKI T. Green Approaches to Sample Preparation Based on Extraction Techniques[J]. Molecules, 2020, 25(7): 1719. doi: 10.3390/molecules25071719
    [28]
    CHESHARI EC, REN X, LI X. Core-shell magnetic Ag-molecularly imprinted composite for surface enhanced Raman scattering detection of carbaryl[J]. J Environ Sci Health B, 2021, 56(3): 222-234. doi: 10.1080/03601234.2020.1869476
    [29]
    WANG G, HUYNH K, BARHATE R, et al. Development of a homogeneous immunoassay for the detection of fentanyl in urine[J]. Forensic Sci Int, 2011, 206(1-3): 127-131. doi: 10.1016/j.forsciint.2010.07.022
    [30]
    QUINTELA O, BERMEJO AM, TABERNERO MJ, et al. Evaluation of cocaine, amphetamines and cannabis use in university students through hair analysis: preliminary results[J]. Forensic Sci Int, 2000, 107(1-3): 273-279. doi: 10.1016/S0379-0738(99)00170-X
    [31]
    MUSSHOFF F, KIRSCHBAUM KM, GRAUMANN K, et al. Evaluation of two immunoassay procedures for drug testing in hair samples[J]. Forensic Sci Int, 2012, 215(1-3): 60-63. doi: 10.1016/j.forsciint.2011.03.030
    [32]
    GOULLÉ JP, CHÈZE M, PÉPIN G. Determination of endogenous levels of GHB in human hair. Are there possibilities for the identification of GHB administration through hair analysis in cases of drug-facilitated sexual assault[J]. J Anal Toxicol, 2003, 27(8): 574-580. doi: 10.1093/jat/27.8.574
    [33]
    MENG P, ZHU D, HE H, et al. Determination of amphetamines in hair by GC/MS after small-volume liquid extraction and microwave derivatization[J]. Anal Sci, 2009, 25(9): 1115-1118. doi: 10.2116/analsci.25.1115
    [34]
    BEGOU O, WEBER K, BECKMANN B, et al. GC-MS Studies on Derivatization of Creatinine and Creatine by BSTFA and Their Measurement in Human Urine[J]. Molecules, 2021, 26(11): 3206. doi: 10.3390/molecules26113206
    [35]
    DULAURENT S, GAULIER JM, IMBERT L, et al. Simultaneous determination of Δ9-tetrahydrocannabinol, cannabidiol, cannabinol and 11-nor-Δ9-tetrahy -drocannabinol-9- carboxylic acid in hair using liquid chromatography- tandem mass spectrometry[J]. Forensic Sci Int, 2014, 236: 151-156. doi: 10.1016/j.forsciint.2014.01.004
    [36]
    HUANG DK, LIU C, HUANG MK, et al. Simultaneous determination of morphine, codeine, 6-acetylmorphine, cocaine and benzoylecgonine in hair by liquid chromatography/electrospray ionization tandem mass spectrometry[J]. Rapid Commun Mass Spectrom, 2009, 23(7): 957-962. doi: 10.1002/rcm.3955
    [37]
    张信仁. 液相色谱-串联质谱法检测食品中芬太尼类新精神活性物质[J]. 化学分析计量, 2023, 32(4): 30-34. doi: 10.3969/j.issn.1008-6145.2023.04.007
    [38]
    NIEBEL A, KRUMBIEGEL F, HARTWIG S, et al. Detection and quantification of synthetic cathinones and selected piperazines in hair by LC-MS/MS[J]. Forensic Sci Med Pathol, 2020, 16: 32-42. doi: 10.1007/s12024-019-00209-z
    [39]
    金涛, 潘本松, 聂洪港. 基质辅助激光解吸电离-质谱成像技术(MALDI-MSI)及其在脑神经性疾病研究中的应用[J]. 计量科学与技术, 2022, 66(3): 3-22.
    [40]
    KEMPSON IM, SKINNER WM, KIRKBRIDE PK. A method for the longitudinal sectioning of single hair samples[J]. J Forensic Sci, 2002, 47: 889-892.
    [41]
    KAMATA T, SHIMA N, SASAKI K, et al. Time-course mass spectrometry imaging for depicting drug incorporation into hair[J]. Anal Chem, 2015, 87: 5476-5481. doi: 10.1021/acs.analchem.5b00971
    [42]
    DUVIVIER WF, VAN BEEK TA, PENNINGS EJ, et al. Rapid analysis of Delta-9-tetrahydrocannabinol in hair using direct analysis in real time ambient ionization orbitrap mass spectrometry[J]. Rapid Commun Mass Spectrom, 2014, 28: 682-690. doi: 10.1002/rcm.6831
    [43]
    NAKANISHI T, NIRASAWA T, TAKUBO T. Quantitative mass barcodelike image of nicotine in single longitudinally sliced hair sections from long-term smokers by matrix-assisted laser desorption timeof-flight mass spectrometry imaging[J]. J Anal Toxicol, 2014, 38: 349-353. doi: 10.1093/jat/bku032
    [44]
    POETZSCH M, STEUER AE, ROEMMELT AT, et al. Single hair analysis of small molecules using MALDI-triple quadrupole MS imaging and LC-MS/MS: investigations on opportunities and pitfalls[J]. Anal Chem, 2014, 86: 11758-11765. doi: 10.1021/ac503193w
    [45]
    GOTTARDO R, FANIGLIULO A, BORTOLOTTI F, et al. Broad-spectrum toxicological analysis of hair based on capillary zone electrophoresis-time-of-flight mass spectrometry[J]. J Chromatogr A, 2007, 1159(1-2): 190-197. doi: 10.1016/j.chroma.2007.05.099
    [46]
    CHÈZE M, DUFFORT G, DEVEAUX M, et al. Hair analysis by liquid chromatography-tandem mass spectrometry in toxicological investigation of drug-facilitated crimes: report of 128 cases over the period June 2003-May 2004 in metropolitan Paris[J]. Forensic Sci Int, 2005, 153(1): 3-10. doi: 10.1016/j.forsciint.2005.04.021
    [47]
    KUWAYAMA K, MIYAGUCHI H, KANAMORI T, et al. Development of an improved method to estimate the days of continuous drug ingestion, based on the micro-segmental hair analysis [J]. Drug Test Anal, 2021, 13(7): 1295-1304. doi: 10.1002/dta.3025
    [48]
    SALOMONE A, GERACE E, DI CORCIA D, et al. Hair analysis can provide additional information in doping and forensic cases involving clostebol[J]. Drug Test Anal, 2019, 11(1): 95-101. doi: 10.1002/dta.2469
    [49]
    KINTZ P, AMELINE A, EIBEL A, et al. Interpretation of Cannabis Findings in the Hair of Very Young Children: Mission Impossible[J]. Curr Pharm Biotechnol, 2017, 18(10): 791-795.
    [50]
    KINTZ P, KIEFFER I, MESSER J, et al. Nicotine analysis in neonates’ hair for measuring gestational exposure to tobacco[J]. J Forensic Sci, 1993, 38(1): 119-123.
    [51]
    HøISETH G, ARNESTAD M, KARINEN R, et al. Is Hair Analysis Useful in Postmortem Cases[J]. J Anal Toxicol, 2018, 42(1): 49-54. doi: 10.1093/jat/bkx077
    [52]
    ASH RD, HE M. Details of a thallium poisoning case revealed by single hair analysis using laser ablation inductively coupled plasma mass spectrometry[J]. Forensic Sci Int, 2018, 292: 224-231. doi: 10.1016/j.forsciint.2018.10.002
    [53]
    PETER OO, ENEJI IS, SHA'ATO R. Analysis of heavy metals in human hair using atomic absorption spectrometry (AAS)[J]. Am J Anal Chem, 2012, 3: 770. doi: 10.4236/ajac.2012.311102
    [54]
    WELCH M, SNIEGOSKI LT, TAI S. Two new standard reference materials for the determination of drugs of abuse in human hair[J]. Anal Bioanal Chem, 2003, 376 (8): 1205-1211. doi: 10.1007/s00216-003-2061-4
    [55]
    韦棋, 苏福海. GC-MS和LC-MS/MS法测定毛发中的6种苯丙胺类药物[J]. 计量科学与技术, 2022, 66(4): 48-54.
    [56]
    LEE S, PARK Y, YANG W, et al. Development of a reference material using methamphetamine abusers' hair samples for the determination of methamphetamine and amphetamine in hair[J]. J Chromatogr B Analyt Technol Biomed Life Sci, 2008, 865 (1-2): 33-39. doi: 10.1016/j.jchromb.2008.01.039
    [57]
    LEE S, PARK Y, HAN E, et al. Preparation and application of a fortified hair reference material for the determination of methamphetamine and amphetamine[J]. Forensic Sci Int, 2008, 178 (2-3): 207-212. doi: 10.1016/j.forsciint.2008.04.005
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(3)

    Article Metrics

    Article views (200) PDF downloads(25) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return