Development of a Certified Reference Material of Three-Component Mixed Solution for GC-MS Calibration

LI Zhifeng; WANG Xiaobing; GUO Shuo; SONG Zengliang

doi:10.12338/j.issn.2096-9015.2023.0197

Volume 67 Issue 7

Jul. 2023

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Article Navigation > Metrology Science and Technology > 2023 > 67(7): 68-73, 44

LI Zhifeng, WANG Xiaobing, GUO Shuo, SONG Zengliang. Development of a Certified Reference Material of Three-Component Mixed Solution for GC-MS Calibration[J]. Metrology Science and Technology, 2023, 67(7): 68-73, 44. doi: 10.12338/j.issn.2096-9015.2023.0197

Citation:

LI Zhifeng, WANG Xiaobing, GUO Shuo, SONG Zengliang. Development of a Certified Reference Material of Three-Component Mixed Solution for GC-MS Calibration[J]. Metrology Science and Technology, 2023, 67(7): 68-73, 44. doi: 10.12338/j.issn.2096-9015.2023.0197

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Development of a Certified Reference Material of Three-Component Mixed Solution for GC-MS Calibration

doi: 10.12338/j.issn.2096-9015.2023.0197

Institute of Metrology of Hebei Province, Shijiazhuang 050227, China

Received Date: 2023-08-22
Accepted Date: 2023-09-04
Rev Recd Date: 2023-09-22

Available Online: 2023-10-16

Publish Date: 2023-07-18

Abstract

Abstract

To address the traceability issue in gas chromatography-mass spectrometry (GC-MS), standard substances are necessitated. A three-component mixed solution, comprising octafluoronaphthalene, benzophenone, and methyl stearate dissolved in isooctane, was meticulously prepared using the gravimetric method for the purpose of gas quality calibration. Analysis was carried out utilizing a gas chromatography equipped with a hydrogen flame ionization detector (GC-FID). Rigorous evaluation was conducted by employing F-tests and regression analysis to assess the homogeneity and stability of the prepared standard substances, as well as the associated uncertainty in the obtained results. Each component in the mixed standard substance yielded calibration values of 3.00 ng/μL with a relative expanded uncertainty U_rel of 3%, at a coverage factor (k) of 2. Comprehensive experimentation involving raw material analysis, preparation of standard materials, assessment of uniformity and stability, and comparison of quantitative values confirmed that the developed standard material fulfills the criteria for national secondary standard substances. Consequently, it has been officially accredited with a certificate number GBW (E) 130677, enabling its utilization in the calibration of GC-MS instruments, specifically for the repeatability testing of retention times.
- metrology,
- octafluoronaphthalene,
- benzophenone,
- methyl stearate,
- certified reference material,
- uncertainty

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References(31)

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